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LncRNA B4GALT1‐AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity
TLDR
The roles and related mechanisms of LncRNA B4GALT1‐AS1 in osteosarcoma cells stemness and migration are revealed and the mechanisms leading to stem cell death are revealed.
Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF‐1α signalling
TLDR
Findings provide new insight into the role of HIF‐1α in the hypoxia induced MSC migration and can be a benefit for the development of MSC‐based therapeutics for wound healing.
Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages
TLDR
It is demonstrated that DAC suppressed RANKL-induced inflammation and osteoclastogenesis and therefore it can be used as a potential treatment for osteoporosis, arthritis, osteolysis, and aseptic loosening of artificial prostheses.
MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice
TLDR
Results indicate that miR-23a may serve as a therapeutic target for the treatment of TBI, as demonstrated by the upregulation of phosphorylated (p‑)AKT and p‑mTOR.
Two Novel Two-Dimensional Lanthanide (III) Coordination Polymers Constructed from Isonicotinic Acid and Iminodiacetic Acid: Synthesis, Structure, and Luminescence Properties
Two novel two-dimensional Ln coordination polymers (CPs) [Ln3 (μ3-OH)(IN)3(HIDA) (IDA)2]n (Ln = Eu, 1; Sm, 2; HIN = isonicotinic acid, and H2IDA = iminodiacetic acid) have been successfully
Role of the HIF-1α/SDF-1/CXCR4 signaling axis in accelerated fracture healing after craniocerebral injury
TLDR
The results indicated that HIF-1α knockdown suppressed MSC proliferation in vitro, and SDF-1 promoted cell migration via binding to CXCR4, which may form a basis for the development of novel strategies for the treatment of craniocerebral injury.
Expression of the Human Glucokinase Gene: Important Roles of the 5′ Flanking and Intron 1 Sequences
TLDR
The results suggest that the normal liver L-02 cell line may be a better model to understand the regulation of the liver-specific expression of the human glucokinase gene, and suggest that sequences downstream of the Liver-specific mRNA start site have important roles in theregulation of liver- specific glucokin enzyme gene expression.
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