Learn More
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
Frequent itemset mining (FIM) is a useful tool for discovering frequently co-occurrent items. Since its inception, a number of significant FIM algorithms have been developed to speed up mining performance. Unfortunately, when the dataset size is huge, both the memory use and computational cost can still be prohibitively expensive. In this work, we propose(More)
We show that an end-to-end deep learning approach can be used to recognize either English or Mandarin Chinese speech–two vastly different languages. Because it replaces entire pipelines of hand-engineered components with neural networks, end-to-end learning allows us to handle a diverse variety of speech including noisy environments, accents and different(More)
Urban sensing, participatory sensing, and user activity recognition can provide rich contextual information for mobile applications such as social networking and location-based services. However, continuously capturing this contextual information on mobile devices consumes huge amount of energy. In this paper, we present a novel design framework for an(More)
In this paper, we have proposed a fingerprint orientation model based on 2D Fourier expansions (FOMFE) in the phase plane. The FOMFE does not require prior knowledge of singular points (SPs). It is able to describe the overall ridge topology seamlessly, including the SP regions, even for noisy fingerprints. Our statistical experiments on a public database(More)
This paper presents PLDA, our parallel implementation of Latent Dirichlet Allocation on MPI and MapReduce. PLDA smooths out storage and computation bottlenecks and provides fault recovery for lengthy distributed computations. We show that PLDA can be applied to large, real-world applications and achieves good scalability. We have released MPI-PLDA to open(More)
Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases, such as the PI3K (phosphatidylinositol 3-kinase)-Akt pathway, the Ras-MAPK (mitogen-activated protein kinase)-RSK (ribosomal S6 kinase) pathway, and the mTOR (mammalian target of rapamycin)-p70 S6 pathway, that control important aspects of cell growth, proliferation,(More)
Users of social networking services can connect with each other by forming communities for online interaction. Yet as the number of communities hosted by such websites grows over time, users have even greater need for effective community recommendations in order to meet more users. In this paper, we investigate two algorithms from very different domains and(More)
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown. Our previous study has shown that autophagy is altered in the mouse model of ALS. In the present study, we systematically investigated the correlation of the autophagic alteration with the motor neurons (MNs)(More)