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We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
Urban sensing, participatory sensing, and user activity recognition can provide rich contextual information for mobile applications such as social networking and location-based services. However, continuously capturing this contextual information on mobile devices consumes huge amount of energy. In this paper, we present a novel design framework for an(More)
Frequent itemset mining (FIM) is a useful tool for discovering frequently co-occurrent items. Since its inception, a number of significant FIM algorithms have been developed to speed up mining performance. Unfortunately, when the dataset size is huge, both the memory use and computational cost can still be prohibitively expensive. In this work, we propose(More)
We show that an end-to-end deep learning approach can be used to recognize either English or Mandarin Chinese speech–two vastly different languages. Because it replaces entire pipelines of hand-engineered components with neural networks , end-to-end learning allows us to handle a diverse variety of speech including noisy environments, accents and different(More)
PURPOSE To compare prostatic arterial embolization (PAE) and transurethral resection of the prostate (TURP) in the care of patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS This prospective randomized clinical trial was approved by the institutional review board. A total of 114 patients provided written informed consent and were(More)
In this paper, we have proposed a fingerprint orientation model based on 2D Fourier expansions (FOMFE) in the phase plane. The FOMFE does not require prior knowledge of singular points (SPs). It is able to describe the overall ridge topology seamlessly, including the SP regions, even for noisy fingerprints. Our statistical experiments on a public database(More)
This paper presents PLDA, our parallel implementation of Latent Dirich-let Allocation on MPI and MapReduce. PLDA smooths out storage and computation bottlenecks and provides fault recovery for lengthy distributed computations. We show that PLDA can be applied to large, real-world applications and achieves good scalability. We have released MPI-PLDA to open(More)
Sister chromatid cohesion is normally established in S phase in a process that depends on the cohesion establishment factor Eco1, a conserved acetyltransferase. However, due to the lack of known in vivo substrates, how Eco1 regulates cohesion is not understood. Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of(More)
For optimal image quality in susceptibility-weighted imaging and accurate quantification of susceptibility, it is necessary to isolate the local field generated by local magnetic sources (such as iron) from the background field that arises from imperfect shimming and variations in magnetic susceptibility of surrounding tissues (including air). Previous(More)