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Bladder cancer is a common urologic cancer whose incidence continues to rise annually. Urinary microparticles are an attractive material for noninvasive bladder cancer biomarker discovery. In this study, we applied isotopic dimethylation labeling coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to discover bladder cancer biomarkers in(More)
Pericytes have been identified as the major source of precursors of scar-producing myofibroblasts during kidney fibrosis. The underlying mechanisms triggering pericyte-myofibroblast transition are poorly understood. Transforming growth factor β-1 (TGF-β1) is well recognized as a pluripotent cytokine that drives organ fibrosis. We investigated the role of(More)
Discrete-time queues are infinite dimensional switches in time. Ever since Shannon published his paper ("Memory requirements in telephone exchange," Bell Syst. Tech. J., pp. 343-349, vol. 29, 1950) on the memory requirements in a telephone exchange, there have been tremendous efforts in the search for switches with minimum complexity. Constructing queues(More)
The epidermal growth factor receptor (EGFR)/RAS/RAF/MEK/MAPK pathway is an important pathway in the carcinogenesis, invasion and metastasis of colorectal cancers (CRCs). We conducted a retrospective study to determine the prognostic values of EGFR expression and KRAS mutation in patients with metastatic CRC (mCRC) based on synchronous or metachronous(More)
OBJECTIVE To evaluate the effects of a 3-month home-based physical therapy (PT) program for patients with hip fracture after surgery. DESIGN Randomized controlled trial. SETTING Home. PARTICIPANTS Twenty-five patients recently discharged from an acute orthopedic department. INTERVENTIONS Patients were randomized to the home-based PT group (n=13),(More)
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder and one of the most common causes of anovulatory infertility. In addition, insulin resistance is commonly associated with PCOS and contributed to pathophysiology connected to dietary minerals including chromium (Cr), copper (Cu), iron (Fe), and zinc (Zn). The aims of this study were to explore(More)
Three common urological diseases are bladder cancer, urinary tract infection, and hematuria. Seventeen bladder cancer biomarkers were previously discovered using iTRAQ - these findings were verified by MRM-MS in this current study. Urine samples from 156 patients with hernia (n=57, control), bladder cancer (n=76), or urinary tract infection/hematuria (n=23)(More)
In this paper, we study the problem of exact emulation of two types of optical queues: (i) <i>N</i>-to-1 output-buffered multiplexers with variable length bursts, and (ii) N times N output-buffered switches with variable length bursts. For both queues, the delay of a packet (in a burst) is known upon its arrival. As such, one can emulate such queues by(More)
We present a multi-instance object segmentation algorithm to tackle occlusions. As an object is split into two parts by an occluder, it is nearly impossible to group the two separate regions into an instance by purely bottomup schemes. To address this problem, we propose to incorporate top-down category specific reasoning and shape prediction through(More)
The purpose of extractive summarization is to automatically select a number of indicative sentences, passages, or paragraphs from the original document according to a target summarization ratio and then sequence them to form a concise summary. In the paper, we proposed the use of probabilistic latent topical information for extractive summarization of(More)