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Bladder cancer is a common urologic cancer whose incidence continues to rise annually. Urinary microparticles are an attractive material for noninvasive bladder cancer biomarker discovery. In this study, we applied isotopic dimethylation labeling coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to discover bladder cancer biomarkers in(More)
Discrete-time queues are infinite dimensional switches in time. Ever since Shannon published his paper ("Memory requirements in telephone exchange," Bell Syst. Tech. J., pp. 343-349, vol. 29, 1950) on the memory requirements in a telephone exchange, there have been tremendous efforts in the search for switches with minimum complexity. Constructing queues(More)
Pericytes have been identified as the major source of precursors of scar-producing myofibroblasts during kidney fibrosis. The underlying mechanisms triggering pericyte-myofibroblast transition are poorly understood. Transforming growth factor β-1 (TGF-β1) is well recognized as a pluripotent cytokine that drives organ fibrosis. We investigated the role of(More)
We present a multi-instance object segmentation algorithm to tackle occlusions. As an object is split into two parts by an occluder, it is nearly impossible to group the two separate regions into an instance by purely bottomup schemes. To address this problem, we propose to incorporate top-down category specific reasoning and shape prediction through(More)
The epidermal growth factor receptor (EGFR)/RAS/RAF/MEK/MAPK pathway is an important pathway in the carcinogenesis, invasion and metastasis of colorectal cancers (CRCs). We conducted a retrospective study to determine the prognostic values of EGFR expression and KRAS mutation in patients with metastatic CRC (mCRC) based on synchronous or metachronous(More)
Microvascular pericytes and perivascular fibroblasts have recently been identified as the source of scar-producing myofibroblasts that appear after injury of the kidney. We show that cross talk between pericytes and endothelial cells concomitantly dictates development of fibrosis and loss of microvasculature after injury. When either platelet-derived growth(More)
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder and one of the most common causes of anovulatory infertility. In addition, insulin resistance is commonly associated with PCOS and contributed to pathophysiology connected to dietary minerals including chromium (Cr), copper (Cu), iron (Fe), and zinc (Zn). The aims of this study were to explore(More)
OBJECTIVE To evaluate the effects of a 3-month home-based physical therapy (PT) program for patients with hip fracture after surgery. DESIGN Randomized controlled trial. SETTING Home. PARTICIPANTS Twenty-five patients recently discharged from an acute orthopedic department. INTERVENTIONS Patients were randomized to the home-based PT group (n=13),(More)
MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. Aberrant lipid and cholesterol metabolism is involved in prostate cancer development and progression to end-stage disease. We recently demonstrated that a key transcription factor for lipogenesis, sterol regulatory(More)