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Bacteria belonging to the genus Paenibacillus are recognized as rich sources of bioactive natural products. To date, there are few characterized siderophores from this genus. Here, through genome analysis, we identified a non-ribosomal peptide biosynthetic gene cluster (pae) responsible for siderophore assembly in Paenibacillus elgii B69. The 12.8 kb gene(More)
Two lipopeptide antibiotics, pelgipeptins C and D, were isolated from Paenibacillus elgii B69 strain. The molecular masses of the two compounds were both determined to be 1,086 Da. Mass-spectrometry, amino acid analysis and NMR spectroscopy indicated that pelgipeptin C was the same compound as BMY-28160, while pelgipeptin D was identified as a new(More)
A gene encoding phytoene desaturase (crtI) in the carotenoid biosynthetic pathway of Sphingomonas elodea ATCC 31461, an industrial gellan gum-producing strain, was cloned and identified. This gene is predicted to encode a 492-amino acid protein with significant homology to the phytoene desaturase of other carotenogenic organisms. Knockout of crtI gene(More)
The recent increase in bacterial resistance to antibiotics has promoted the exploration of novel antibacterial materials. As a result, many researchers are undertaking work to identify new lantibiotics because of their potent antimicrobial activities. The objective of this study was to provide details of a lantibiotic-like gene cluster in Paenibacillus(More)
OBJECTIVE Increasing evidence suggests that, when used in combination, tumor necrosis factor-α (TNF-α) synergizes with traditional chemotherapeutic drugs to exert a heightened antitumor effect. The present study investigated the antitumor efficacy of recombinant mutated human TNF-α specifically targeted to the tumor vasculature (RGD-rmhTNF-α) combined with(More)
Hospital-acquired infections caused by drug-resistant bacteria are a significant challenge to patient safety. Numerous clinical isolates resistant to almost all commercially available antibiotics have emerged. Thus, novel antimicrobial agents, specifically those for multidrug-resistant Gram-negative bacteria, are urgently needed. In the current study, we(More)
We firstly analyze the method for four attack types, including Probing, DoS (Denial of Service), R2L (Remote to Local) and U2R (User to Root). Based on resource addresses and destination addresses of the network packages, attacks can be divided into four cases, which are respectively one host-one host, one host-many hosts, many hosts-one host and many(More)
OBJECTIVE To identify the relationship between amino acid mutations in Neisseria gonorrhoeae isolates and their antibiotic resistance. METHODS PI gene fragments of Neisseria gonorrhoeae from 17 clinical isolates were obtained with PCR amplification. They were cloned into the PCR cloning vector pBS-T to form pBS-T-PI and sequenced. The sequences of PI(More)
Correction It has come to our attention that we have used Asp, rather than the correct annotation of Asn, to indicate Asparagine throughout the text [1]. In the abstract this is corrected to: The N-terminal sequence of elgicin B was Leu-Gly-Asn-Tyr, which corresponded to the partial sequence of the peptide ElgA encoded by elgA. In the Results section,(More)
OBJECTIVE The M235T polymorphism in the angiotensinogen gene has been reported to be associated with the development of atrial fibrillation (AF).However, results from observational studies are conflicting. METHODS PubMed, google scholar and China National Knowledge Infrastructure database(2000.1-2013.4) were searched for eligible articles; four separate(More)
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