Yi Ren

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Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about its anti-tumor mechanism in small cell lung cancer (SCLC). In this study, we found that curcumin can inhibit SCLC cell proliferation, cell cycle, migration, invasion and angiogenesis through suppression(More)
Ovarian cancer remains the leading cause of death in gynecologic malignancies partially because of resistance to chemotherapy. In the present study, we show that RY-2f, a chemically synthesized isoflavone analog, inhibited ovarian cancer cell proliferation, blocked cell cycle in G2/M phase and induced cellular apoptosis through up-regulation of p21, cyclin(More)
The factors driving the composition of gut microbiota are still only partly understood but appear to include environmental, cultural, and genetic factors. In order to obtain more insight into the relative importance of these factors, we analyzed the microbiome composition in subjects of Tibetan or Han descent living at different altitudes. DNA was isolated(More)
Environmental effects are not considered sufficiently in product design. Reliability problems caused by environmental effects are very prominent. This paper proposes a method to apply ontology approach in product design. During product reliability design and analysis, environmental effects knowledge reusing is achieved. First, the relationship of(More)
Strength reduction method and ADINA software are adopted to study the stability of submarine tunnel structures subjected to seepage and earthquake under different seawater depths and overlying rock strata thicknesses. First, the excess pore water pressure in the rock mass is eliminated through consolidation calculation. Second, dynamic time-history analysis(More)
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