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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. However, to date, the… Expand
Early Childhood Investments Substantially Boost Adult Health
Look After the Child Investing in children has been demonstrated to improve their lives, both during the school-age years and afterward, as assessed by outcomes such as employment and income;… Expand
Expansion of human SCID-repopulating cells under hypoxic conditions.
- G. H. Danet, Yi Pan, J. Luongo, D. Bonnet, M. Simon
- Biology, Medicine
- The Journal of clinical investigation
- 1 July 2003
It has been proposed that bone marrow (BM) hematopoietic stem and progenitor cells are distributed along an oxygen (O2) gradient, where stem cells reside in the most hypoxic areas and proliferating… Expand
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.
While cellular responses to low oxygen (O(2)) or hypoxia have been studied extensively, the precise identity of mammalian cellular O(2) sensors remains controversial. Using murine embryonic cells… Expand
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
- Yi Pan, K. Mansfield, +4 authors M. Simon
- Biology, Medicine
- Molecular and Cellular Biology
- 13 November 2006
ABSTRACT Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-α) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in… Expand
Stateful Scalable Stream Processing at LinkedIn
- Shadi A. Noghabi, K. Paramasivam, +4 authors R. Campbell
- Computer Science
- Proc. VLDB Endow.
- 1 August 2017
Distributed stream processing systems need to support stateful processing, recover quickly from failures to resume such processing, and reprocess an entire data stream quickly. Expand
Adropin Is a Novel Regulator of Endothelial Function
Background— Adropin is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance. Because vascular function and insulin sensitivity are… Expand
Adult outcomes as a function of an early childhood educational program: an Abecedarian Project follow-up.
- F. Campbell, E. Pungello, +6 authors C. Ramey
- Psychology, Medicine
- Developmental psychology
- 16 January 2012
Adult (age 30) educational, economic, and social-emotional adjustment outcomes were investigated for participants in the Abecedarian Project, a randomized controlled trial of early childhood… Expand
Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor
Platelets play a significant role in atherosclerosis, stroke, and asthma through active interaction with neutrophils, monocytes, and vascular endothelial cells. The mechanism underlying these… Expand
MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
BackgroundPatients with hematogenous metastatic lung cancer displayed significantly increased platelet count and aggregation compared to lung cancer patients without hematogenous metastasis. The… Expand