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- Publications
- Influence
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa.
- Yi-Ming Chiang, Da-Yung Chuang, S. Wang, Y. Kuo, Pi-Wen Tsai, L. Shyur
- Chemistry, Medicine
- Journal of ethnopharmacology
- 1 December 2004
Bidens pilosa has been used as a folk medicine in various medications and as a popular ingredient in herb teas. Chemopreventive activities of crude and fractionated plant extracts of Bidens pilosa… Expand
Chromatin-level regulation of biosynthetic gene clusters.
- J. W. Bok, Yi-Ming Chiang, +9 authors N. Keller
- Biology, Medicine
- Nature chemical biology
- 1 July 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new… Expand
Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans
- Edyta Szewczyk, Yi-Ming Chiang, C. Oakley, A. D. Davidson, C. Wang, B. Oakley
- Biology, Medicine
- Applied and Environmental Microbiology
- 31 October 2008
ABSTRACT The sequencing of Aspergillus genomes has revealed that the products of a large number of secondary metabolism pathways have not yet been identified. This is probably because many secondary… Expand
Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway.
- Yi-Ming Chiang, Edyta Szewczyk, +10 authors C. Wang
- Biology, Medicine
- Chemistry & biology
- 23 June 2008
The recently sequenced genomes of several Aspergillus species have revealed that these organisms have the potential to produce a surprisingly large range of natural products, many of which are… Expand
Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.
- Manmeet Ahuja, Yi-Ming Chiang, +7 authors C. Wang
- Chemistry, Medicine
- Journal of the American Chemical Society
- 16 May 2012
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been… Expand
Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells.
- C. Wang, Yi-Ming Chiang, Shu-Chiao Sung, Y. Hsu, Jiunn-Kae Chang, Po-Lin Kuo
- Biology, Medicine
- Cancer letters
- 18 January 2008
This study is the first to investigate the anticancer effect of plumbagin in human melanoma A375.S2 cells. Plumbagin exhibited effective cell growth inhibition by inducing cancer cells to undergo… Expand
A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans.
- Yi-Ming Chiang, Edyta Szewczyk, A. D. Davidson, N. Keller, B. Oakley, C. Wang
- Chemistry, Medicine
- Journal of the American Chemical Society
- 4 March 2009
The genome sequencing of Aspergillus species including A. nidulans reveals that the products of many of the secondary metabolism pathways in these fungi have not been elucidated. Our examination of… Expand
An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.
- Yi-Ming Chiang, C. Oakley, +6 authors B. Oakley
- Chemistry, Medicine
- Journal of the American Chemical Society
- 22 May 2013
Fungal secondary metabolites (SMs) are an important source of medically valuable compounds. Genome projects have revealed that fungi have many SM biosynthetic gene clusters that are not normally… Expand
Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster
- Yi-Ming Chiang, Edyta Szewczyk, +4 authors B. Oakley
- Biology, Medicine
- Applied and Environmental Microbiology
- 5 February 2010
ABSTRACT Deletion of cclA, a component of the COMPASS complex of Aspergillus nidulans, results in the production of monodictyphenone and emodin derivatives. Through a set of targeted deletions in a… Expand
Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.
- J. F. Sánchez, Ruth A Entwistle, +5 authors B. Oakley
- Chemistry, Medicine
- Journal of the American Chemical Society
- 23 March 2011
Xanthones are a class of molecules that bind to a number of drug targets and possess a myriad of biological properties. An understanding of xanthone biosynthesis at the genetic level should… Expand