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Drosophila and leech models of nervous system development demonstrate that protein tyrosine phosphatase (PTP) receptors regulate developmental neurite outgrowth. Whether PTP receptors regulate neurite outgrowth in adult systems or in regenerative states remains unknown. The leukocyte common antigen-related (LAR) receptor is known to be present in rodent(More)
Cyclized peptides corresponding to beta-loop regions of NGF were purified by HPLC and assayed for neurotrophic activity using DRG neurons. Peptides with the highest activity corresponded to loop region 29-35, a domain likely to interact with the p75 receptor. Unexpectedly, activity was confined to late-eluting HPLC fractions containing peptide multimers and(More)
Previous work indicating that nerve growth factor (NGF) protein loops 2 and 4 interact with TrkA receptors raise the possibility that small molecule mimetics corresponding to TrkA-interacting domains that have NGF agonist activity can be developed. We applied our previously developed strategy of dimeric peptidomimetics to address the hypothesis that loop 4(More)
The principal stress based Evolutionary Structural Optimisation (ESO) method is presented herein for topology optimisation of arch, tied arch, cable-stayed and suspension bridges with both stress and displacement constraints. Two performance index formulas are developed to determine the efficiency of the topology design. A refined mesh scheme is proposed to(More)
Evolutionary structural optimization (ESO) has been shown through much published research to be a simple and yet effective method for structural shape and topology optimization. However, attention has been drawn to shortcomings in the method related to the computational efficiency of the algorithm as well as the jagged edge representation of the Finite(More)
The identity of the protein tyrosine phosphatases (PTPs) regulating cell death and responses to neurotrophins during neural development remain unknown. To determine if the leukocyte common antigen-related (LAR) PTP regulates these processes, PC12 cells were made LAR-deficient via stable transfection with an LAR antisense transgene. LAR-deficient cells(More)
Group evolutionary structural optimization (GESO) is a recent modi®cation of evolutionary structural optimization (ESO) that extends the topological method to con®guration optimization. This paper demonstrates the optimization of an aircraft wing with ESO and GESO. The optimization is conducted over some of the major areas involved in the design of an(More)
We describe an optically assisted folding-flash analog-to-digital converter. The periodic transfer function of the Mach-Zehnder interferometer is used to perform analog folding on the electronic signal to be quantized. A novel analog encoding scheme for efficient generation of gray code digital data is proposed. The new encoding scheme eliminates the(More)
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