Learn More
CONTEXT The tryptophan hydroxylase 2 (TPH2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. Despite reports of possible associations between polymorphisms in human TPH2 and many psychiatric disorders, including bipolar disorder (BPD), the functional effect and susceptibility loci of such polymorphisms for BPD(More)
As China becomes more influential in the global politics and economy, Mandarin is likely to become an international lingua franca in the near future. Although the importance of learning Chinese seems to be well aware of, learning it is deemed exceptionally difficult for non-native Chinese speakers. The purpose of this paper is to describe the design(More)
BACKGROUND Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Although several pieces of evidence suggested that MAOA is important in the etiology of bipolar affective disorder (BPD), associations for markers of the MAOA gene with BPD were not conclusive and the association(More)
BACKGROUND Disturbances in serotonin neurotransmission are implicated in the etiology of many psychiatric disorders, including bipolar affective disorder (BPD). The tryptophan hydroxylase gene (TPH), which codes for the enzyme catalyzing the rate-limiting step in serotonin biosynthetic pathway, is one of the leading candidate genes for psychiatric and(More)
B ipolar affective disorder (BPD), a common severe mood disorder characterised by manic and depressive episodes, has an estimated lifetime prevalence of 0.1%–1% in various populations, including that of Taiwan. 1 Although previous studies have strongly suggested the involvement of genetic factors in the aetiology of BPD, the search for predisposing genes(More)
In this study, harmine liposomes (HM-lip) were prepared through the thin-film hydration-pH-gradient method and then coated with N-trimethyl chitosan (TMC). Particle size, zeta potential, entrapment efficiency, and in vitro release of HM-lip and TMC-coated harmine liposomes (TMC-HM-lip) were also determined. Sprague Dawley rats were further used to(More)
Bladder cancer is one of the major cancer types and both environmental factors and genetic background play important roles in its pathology. Kaohsiung is a high industrialized city in Taiwan, and here we focused on this region to evaluate the genetic effects on bladder cancer. Muscarinic acetylcholine receptor M3 (CHRM3) was reported as a key receptor in(More)
Capsaicin has been reported to preferentially inhibit the activity of tumor-associated NADH oxidase (tNOX), which belongs to a family of growth-related plasma membrane hydroquinone oxidases in cancer/transformed cells. The inhibitory effect of capsaicin on tNOX is associated with cell growth attenuation and apoptosis. However, no previous study has examined(More)
The paper introduces a 3D online role playing simulation and game targeted at people who learn Chinese as their second language. In order to ease the cultural barriers while learning language, the simulation and game is implemented in an immersive learning environment featuring on an ancient China village. The village is designed with metaphorical(More)
Social theories of learning argue that people learn through participation in activities. While there is recognition of the enabling role of information technologies in education, scholars have suggested that more research should explore the relationship between media and the socio-cultural construction of knowledge. This study examines how blogs, a recent(More)