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Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
This work transplanted both human SCAP and periodontal ligament stem cells to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function and recovery of tooth strength and appearance.
Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study.
Mesenchymal Stem Cell-Based Tissue Regeneration is Governed by Recipient T Lymphocyte via IFN-γ and TNF-α
It is shown that proinflammatory T cells inhibit the ability of exogenously added bone marrow mesenchymal stem cells (BMMSCs) to mediate bone repair, and a previously unrecognized role of recipient T cells in BMMSC-based tissue engineering is shown.
Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis1
Takeaway is that gingiva-derived mesenchymal stem cells can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases.
The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering.
Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity
It is found that vitamin C (Vc) was capable of inducing telomerase activity in periodontal ligament stem cells (PDLSCs), leading to the up‐regulated expression of extracellular matrix type I collagen, fibronectin, and integrin β1, stem cell markers Oct4, Sox2, and Nanog as well as osteogenic markers RUNX2, ALP, OCN.
Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
The immunomodulatory properties of SHED in comparison to BMMSCs were examined and it was found that SHED had significant effects on inhibiting T helper 17 (Th17) cells in vitro and in vivo.
Periodontal Ligament Stem Cell‐Mediated Treatment for Periodontitis in Miniature Swine
The feasibility of using stem cell‐mediated tissue engineering to treat periodontal diseases is demonstrated and it is demonstrated that PDLSCs were capable of regeneratingperiodontal tissues, leading to a favorable treatment for periodontitis.
Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice.