Yi Lao

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Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures(More)
OBJECTIVE Traumatic brain injury in contact sports has significant impact on short-term neurologic and neurosurgical function as well as longer-term cognitive disability. In this study, we aim to demonstrate that contact sport participants exhibit differences in diffusion tensor imaging (DTI) caused by repeated physical impacts on the brain. We also aim to(More)
Blindness represents a unique model to study how visual experience may shape the development of brain organization. Exploring how the structure of the corpus callosum (CC) reorganizes ensuing visual deprivation is of particular interest due to its important functional implication in vision (e.g., via the splenium of the CC). Moreover, comparing early versus(More)
We propose a novel framework to capture a complete set of 3D morphological differences in the corpus callosum (CC) between two groups of subjects. The CCs are segmented from whole brain T1-weighted magnetic resonance images and modeled as 3D tetrahedral meshes. The callosal surface is divided into superior and inferior patches on which we compute a(More)
Preterm neonates are at higher risk of neurocognitive and neurosensory abnormalities. While numerous studies have looked at the effect of prematurity on brain anatomy, none to date have attempted to understand the relative pose of subcortical structures and to assess its potential as a biomarker of abnormal growth. Here, we perform the first relative pose(More)
1 Abstract Mild traumatic brain injury (MTBI) or concussive injury affects 1.7 million Americans annually, of which 300,000 are due to recreational activities and contact sports, such as football, rugby, and boxing[1]. Finding the neu-roanatomical correlates of brain TBI non-invasively and precisely is crucial for diagnosis and prognosis. Several studies(More)
Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization of the abnormalities within the subnuclei(More)
Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on(More)
A T1 and DTI fused 3D Corpus Callosum analysis in MCI subjects with high and low cardiovascular risk profile, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the(More)
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may(More)