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Pericellular hydrogel/nanonets inhibit cancer cells.
Pericellular hydrogel/nanonets of small molecules to exhibit distinct functions illustrates a fundamentally new way to engineer molecular assemblies spatiotemporally in cellular microenvironment for inhibiting cancer cell growth and even metastasis.
D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID).
- Jiayang Li, Yi Kuang, Yuan Gao, Xuewen Du, Junfeng Shi, Bing Xu
- BiologyJournal of the American Chemical Society
- 16 January 2013
This work illustrates a previously unexplored approach that employs d-amino acids for the development of functional molecules that have dual or multiple roles and exceptional biostability, which offers a new class of molecular hydrogels of therapeutic agents.
FePt@CoS(2) yolk-shell nanocrystals as a potent agent to kill HeLa cells.
- Jinhao Gao, G. Liang, Bei Zhang, Yi Kuang, Xixiang Zhang, Bing Xu
- ChemistryJournal of the American Chemical Society
- 11 January 2007
The exceptionally high toxicity of FePt@CoS(2) yolk-shell nanocrystals (about 7 times higher than that of cisplatin in terms of Pt) may lead to a new design of an anticancer nanomedicine.
Multifunctional yolk-shell nanoparticles: a potential MRI contrast and anticancer agent.
It is indicated that these unique yolk-shell nanoparticles may ultimately lead to new designs of multifunctional nanostructures for nanomedicine, and may serve both as an MRI contrast agent and as a potent anticancer drug.
Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative.
- Yuan Gao, Yi Kuang, Zu-feng Guo, Zhihong Guo, I. Krauss, Bing Xu
- Biology, Materials ScienceJournal of the American Chemical Society
- 4 September 2009
This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells.
The use of enzyme-instructed self-assembly (EISA) to generate intracellular supramolecular assemblies that drastically boost the activity of cisplatin against drug-resistant ovarian cancer cells are shown.
Supramolecular nanofibers and hydrogels of nucleopeptides.
- Xinming Li, Yi Kuang, Hsin‐Chieh Lin, Yuan Gao, Junfeng Shi, Bing Xu
- Biology, ChemistryAngewandte Chemie
- 26 September 2011
generates of nucleopeptides as biocompatible with nucleobases, this work provides a facile way to explore the new applications of nucleopeptides as functional biomaterials.
Multifunctional, biocompatible supramolecular hydrogelators consist only of nucleobase, amino acid, and glycoside.
- Xinming Li, Yi Kuang, Junfeng Shi, Yuan Gao, Hsin‐Chieh Lin, Bing Xu
- Biology, ChemistryJournal of the American Chemical Society
- 2 November 2011
This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels
- Jiayang Li, Yi Kuang, Junfeng Shi, Yuan Gao, Jie Zhou, Bing Xu
- Biology, Materials ScienceBeilstein journal of organic chemistry
- 10 May 2013
It is demonstrated that common NSAIDs are excellent candidates to promote aromatic–aromatic interaction in water to form hydrogels, and this work contributes to the development of functional molecules that have dual or multiple roles and ultimately may lead to new molecular Hydrogels of therapeutic agents for topical use.
Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules.
This work has illustrated the first example of morphological dependent protein binding of nanoscale molecular aggregates with different morphologies that interact with cytosol proteins in a drastically different manner.