Yi-Jou Wang

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Areca nut is the most widely used psychoactive substance and an important environmental risk factor for development of oral premalignant lesions and cancer. Arecoline, the major alkaloid of areca nut, has been known to cause cytotoxicity and genotoxicity in mammalian cells in vivo and in vitro and even contributes to carcinogenicity. However, the(More)
  • Y Wang
  • Journal of clinical oncology : official journal…
  • 2011
e13517 Background: Human neutrophil peptides (HNP1-3) are expressed within tumors and exhibit extensive cytotoxicity to various tumor cells in vitro. The anti-tumoral mechanisms of HNP1-3 involve in damage on cell membranes and mitochondria. The expression of HNP1-3 within tumors may thus improve the therapeutic effects of chemotherapy. METHODS Here, we(More)
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