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LetX be a compact oriented Riemannian manifold and let φ : X → S be a circle-valued Morse function. Under some mild assumptions on φ, we prove a formula relating: (a) the number of closed orbits of the gradient flow of φ of any given degree; (b) the torsion of a “Morse complex”, which counts gradient flow lines between critical points of φ; and (c) a kind(More)
This is an expansion on my talk at the Geometry and Topology conference at McMaster University, May 2004. We outline a program to relate the Heegaard Floer homologies of Ozsvath-Szabo, and Seiberg-Witten-Floer homologies as defined by Kronheimer-Mrowka. The center-piece of this program is the construction of an intermediate version of Floer theory, which(More)
Various Seiberg-Witten Floer cohomologies are defined for a closed, oriented 3-manifold; and if it is the mapping torus of an area-preserving surface automorphism, it has an associated periodic Floer homology as defined by Michael Hutchings. We construct an isomorphism between a certain version of SeibergWitten Floer cohomology and the corresponding(More)
BACKGROUND AND PURPOSE As prognosis for patients with metastatic ovarian cancer is generally poor, advances in treatment are needed. Here, we studied the mechanism of action of a recombinant viral capsid protein (rVP1) and explored its effect against ovarian tumour growth and metastasis in vivo. EXPERIMENTAL APPROACH The human ovarian cancer cell line(More)
Protein arginine methyltransferase (PRMT) 1 is the most conserved and widely distributed PRMT in eukaryotes. PRMT8 is a vertebrate-restricted paralogue of PRMT1 with an extra N-terminal sequence and brain-specific expression. We use zebrafish (Danio rerio) as a vertebrate model to study PRMT8 function and putative redundancy with PRMT1. The transcripts of(More)
We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical(More)
The preparation and cytotoxicity properties of a series of N(epsilon)-substituted triamine-linked acridine dimers are described. Most acridine dimer derivatives reveal highly potent in vitro cytotoxicity properties and DNA binding activity. Several acridine dimers were selected to study their action in vivo. These acridine dimers have demonstrated a narrow(More)
The availability of adequate cancer stem cells or cancer stem-like cell (CSC) is important in cancer study. From ovarian cancer cell lines, SKOV3 and OVCAR3, we induced peritoneal ascites tumors in immunodeficient mice. Among the cells (SKOV3.PX1 and OVCAR3.PX1) from those tumors, we sorted both CD44 and CD133 positive cells (SKOV3.PX1_133+44+,(More)
We have shown previously that the Epstein-Barr virus nuclear antigen-1 (EBNA1) can act as a transforming suppressor in the HER2/neu-overexpressing ovarian cancer cells. In the present study, by using flow cytometric analysis, we demonstrate that EBNA1 could prolong G(2)/M phase and sensitize to Taxol-induced apoptosis in the EBNA1-expressing ovarian cancer(More)