Yi-Han Hsiao

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STUDY OBJECTIVES To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN Cohort study. SETTING Nationwide database research. PARTICIPANTS 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent(More)
BACKGROUND Treatment of COPD with a combination of long-acting β(2) agonists and corticosteroids is currently used worldwide. The mechanisms of the anti-inflammatory effects and their associations with histone deacetylase (HDAC) activity remain unclear. METHODS Human alveolar macrophages were isolated and stimulated with H(2)O(2) in the presence of(More)
Bone marrow-derived mesenchymal stem cells (BM-MSC) can be differentiated into lung epithelial-like cells (MSC-EC) in vitro. The response of BM-MSC and MSC-EC to stimuli may vary because of their character and differentiation. We aimed to investigate the factors that may influence in vitro differentiation of BM-MSC to MSC-EC. We determined the response of(More)
BACKGROUND Seasonal variations in the acute exacerbation of chronic obstructive pulmonary disease (COPD) have been reported. However, the influence of air temperature and other meteorological factors on COPD exacerbation remains unclear. METHODS National Health Insurance registry data from January 1, 1999 to December 1, 2009 and meteorological variables(More)
Gesture-recognition is an important component for many intelligent human–computer interaction applications. For example, a realtime sign-language recognition system would detect and interpret hand gestures. Many vision-based sign-language recognition methods have been proposed over the years with mix results of usability. Some system are limited to(More)
BACKGROUND In recent years, intensive care for cancer patients has improved and treatment of critically ill cancer patients has become increasingly aggressive over time. However, not all cancer patients would benefit from aggressive care, especially those with late-stage cancer. OBJECTIVE We aimed to investigate the outcome of late-stage lung cancer(More)
This work investigates the efficacy of multiple-jet nozzles in reducing exposure to noise radiated from high-speed jet flows that are frequently used for cleaning and other purposes. A single-jet nozzle is replaced by one with multiple and smaller outlets with the same combined exit area. Noise generated by multiple-jet nozzles will shift to higher(More)
BACKGROUND While Candida pneumonia is life-threatening, biomarker measurements to early detect suspected Candida pneumonia are lacking. This study compared the diagnostic values of measuring levels of (1, 3)-β-D-glucan in endotracheal aspirate, bronchoalveolar lavage fluid, and serum to detect suspected Candida pneumonia in immunocompromised and critically(More)
BACKGROUND AND OBJECTIVE Bile acid (BA) aspiration is associated with various lung diseases. It was hypothesized that BA may induce changes in alveolar epithelium permeability and contribute to the pathogenesis of lung injury. METHODS Human alveolar epithelial cells were grown in monolayer and stimulated with a major component of BA, chenodeoxycholic acid(More)
BACKGROUND Expression of transforming growth factor (TGF)-β1 and increases in angiogenesis and deposition of extracellular matrix are the key features of tracheal granulation formation. The aim of this study was to investigate the potential role of thalidomide in preventing granulation tissue formation from the aspect of cellular effects in vitro, including(More)