Yi-Han Hsiao

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STUDY OBJECTIVES To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN Cohort study. SETTING Nationwide database research. PARTICIPANTS 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent(More)
BACKGROUND In recent years, intensive care for cancer patients has improved and treatment of critically ill cancer patients has become increasingly aggressive over time. However, not all cancer patients would benefit from aggressive care, especially those with late-stage cancer. OBJECTIVE We aimed to investigate the outcome of late-stage lung cancer(More)
BACKGROUND Seasonal variations in the acute exacerbation of chronic obstructive pulmonary disease (COPD) have been reported. However, the influence of air temperature and other meteorological factors on COPD exacerbation remains unclear. METHODS National Health Insurance registry data from January 1, 1999 to December 1, 2009 and meteorological variables(More)
Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study. Ninety COPD patients without past medical history of asthma or allergic(More)
Bone marrow-derived mesenchymal stem cells (BM-MSC) can be differentiated into lung epithelial-like cells (MSC-EC) in vitro. The response of BM-MSC and MSC-EC to stimuli may vary because of their character and differentiation. We aimed to investigate the factors that may influence in vitro differentiation of BM-MSC to MSC-EC. We determined the response of(More)
BACKGROUND AND OBJECTIVE The efficacy of budesonide/formoterol maintenance and reliever therapy (BFMRT) in asthma control is well documented in large randomized controlled trials. However, the acute reliever effects and real-life effectiveness are seldom reported. METHODS This multicenter trial enrolled steroid-naïve, symptomatic asthmatics with baseline(More)
Gesture-recognition is an important component for many intelligent human–computer interaction applications. For example, a realtime sign-language recognition system would detect and interpret hand gestures. Many vision-based sign-language recognition methods have been proposed over the years with mix results of usability. Some system are limited to(More)
BACKGROUND Treatment of COPD with a combination of long-acting β(2) agonists and corticosteroids is currently used worldwide. The mechanisms of the anti-inflammatory effects and their associations with histone deacetylase (HDAC) activity remain unclear. METHODS Human alveolar macrophages were isolated and stimulated with H(2)O(2) in the presence of(More)
BACKGROUND AND OBJECTIVE Bile acid (BA) aspiration is associated with various lung diseases. It was hypothesized that BA may induce changes in alveolar epithelium permeability and contribute to the pathogenesis of lung injury. METHODS Human alveolar epithelial cells were grown in monolayer and stimulated with a major component of BA, chenodeoxycholic acid(More)
This work investigates the efficacy of multiple-jet nozzles in reducing exposure to noise radiated from high-speed jet flows that are frequently used for cleaning and other purposes. A single-jet nozzle is replaced by one with multiple and smaller outlets with the same combined exit area. Noise generated by multiple-jet nozzles will shift to higher(More)