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We consider the task of learning to accurately follow a trajectory in a vehicle such as a car or helicopter. A number of dynamic programming algorithms such as Differential Dynamic Programming (DDP) and Policy Search by Dynamic Programming (PSDP), can efficiently compute non-stationary policies for these tasks --- such policies in general are well-suited to(More)
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1-/- but not Rac2-/- HSC/Ps fail to engraft in the bone marrow of irradiated(More)
Next-generation computation-intensive applications in various fields of science and engineering feature large-scale computing workflows with complex structures that are often modeled as directed acyclic graphs. Supporting such task graphs and optimizing their end-to-end network performances in heterogeneous computing environments are critical to the success(More)
Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Some leukemia stem cells (LSC) were multipotent and could be lineage directed by altering either the growth factors or the(More)
—In this paper we study the problem of content-based image retrieval. In this problem, the most popular performance measure is the top precision measure, and the most important component of a retrieval system is the similarity function used to compare a query image against a database image. However, up to now, there is no existing similarity learning method(More)
P-glycoprotein (P-gp) is an ATP-dependent efflux transporter highly expressed in gastrointestinal tract and multidrug resistance tumor cells. Inhibition or induction of P-gp can cause drug-drug interactions and thus influence the effects of P-gp substrate drugs. Previous studies indicated that 20(S)-ginsenoside Rh2 [20(S)-Rh2] could synergistically enhance(More)
1. AFM cantilever as load sensor Figure S-1 shows the shape of the AFM cantilever used in the buckling tests. As can be seen from Fig. S-1(a), there are two long and two short cantilevers aligned on one side. In our experiments, NWs were pushed against the long cantilever, as shown in Fig. S-1(b). The deflection can be measured with the neibouring long(More)
A fundamental challenge for time-varying volume data analysis and visualization is the lack of capability to observe and track data change or evolution in an occlusion-free, controllable, and adaptive fashion. In this paper, we propose to organize a timevarying data set into a hierarchy of states. By deriving transition probabilities among states, we(More)
Large-scale computation-intensive applications in various science fields feature complex DAG-structured workflows comprised of distributed computing modules with intricate inter-module dependencies. Supporting such workflows in heterogeneous network environments and optimizing their end-to-end performance are crucial to the success of large-scale(More)