Yi-Fei Huang

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PURPOSE To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons. METHODS Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and(More)
BACKGROUND inhibition of L-type Ca(2+) current contributes to negative inotropy of β(3) adrenergic receptor (β(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and(More)
BACKGROUND The mechanism by which glucose-insulin-potassium solutions enhance recovery of left ventricular function after myocardial ischemia in diabetic patients is not well understood. We evaluated the effect of glucose-insulin-potassium on ventriculoarterial coupling and left ventricular mechanics in a chronic ovine model of diabetes. METHODS Diabetes(More)
We have applied wide-angle X-ray scattering to the human cornea in order to quantify the relative number of stromal collagen fibrils directed along the two preferred corneal lamellar directions: superior-inferior and nasal-temporal. The data suggest that, on average, the two directions are populated in equal proportion at the corneal centre. Here,(More)
PURPOSE To evaluate the efficacy and safety of orally administered sodium fluorescein to stain the clear vitreous before vitrectomy for proliferative diabetic retinopathy (PDR). METHODS Twenty-two consecutive eyes of 20 patients with PDR and five eyes of five patients with proliferative vitreoretinopathy (PVR) were included. The average patient age was 52(More)
PURPOSE To evaluate the biomechanical properties of the cornea using Corneal Visualization Scheimpflug Technology (CorVis ST, Oculus) in eyes with primary open-angle glaucoma (POAG) and normal control eyes. METHODS A comparative cross-sectional study that included 42 patients with POAG and 60 normal control subjects matched for intraocular pressure (IOP)(More)
AIM To investigate the difference in kappa angle between sitting and supine positions during laser-assisted in situ keratomileusis (LASIK). METHODS A retrospective study was performed on 395 eyes from 215 patients with myopia that received LASIK. Low, moderate, and high myopia groups were assigned according to diopters. The horizontal and vertical(More)
Background—Inhibition of L-type Ca 2ϩ current contributes to negative inotropy of ␤ 3 adrenergic receptor (␤ 3 AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na ϩ-K ϩ pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na ϩ levels and upregulation of(More)
The Boston Keratoprosthesis (KPro) is one of several types of artificial cornea manufactured worldwide that are being implanted in increasing numbers in patients with severe corneal diseases and graft failures. To summerize the advances in design of the Boston type I keratoprosthesis and in the treatment strategies to conquer the post operative(More)
BACKGROUND Gefitinib is a promising agent for the treatment of non-small cell lung cancer. The purpose of this study was to develop a novel liposomal formulation for gefitinib (L-GEF) to improve its therapeutic index. MATERIALS AND METHODS Several L-GEF formulations were prepared and characterized for their physical chemical properties and cytotoxicity.(More)