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Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming.
Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation.Expand
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Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.
Pathway-targeted cancer drugs can produce dramatic responses that are invariably limited by the emergence of drug-resistant cells. We found that many drug-treated "oncogene-addicted" cancer cellsExpand
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Anchored multiplex PCR for targeted next-generation sequencing
We describe a rapid target enrichment method for next-generation sequencing, termed anchored multiplex PCR (AMP), that is compatible with low nucleic acid input from formalin-fixed paraffin-embeddedExpand
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Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type: differentiation in the erythroid lineage or oncogenesis in the T‐cell lineage.Expand
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Global and gene‐specific analyses show distinct roles for Myod and Myog at a common set of promoters
We used a combination of genome‐wide and promoter‐specific DNA binding and expression analyses to assess the functional roles of Myod and Myog in regulating the program of skeletal muscle geneExpand
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Genetic and epigenetic determinants of neurogenesis and myogenesis.
The regulatory networks of differentiation programs have been partly characterized; however, the molecular mechanisms of lineage-specific gene regulation by highly similar transcription factorsExpand
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An Arabidopsis Soil-Salinity–Tolerance Mutation Confers Ethylene-Mediated Enhancement of Sodium/Potassium Homeostasis[W]
The soil salinity tolerance of an Arabidopsis mutant is shown to be caused by a mutation in the ETO1 gene that results in ethylene overproduction. Increased ethylene causes root stele reactive oxygenExpand
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Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation.
Alternate splicing contributes extensively to cellular complexity by generating protein isoforms with divergent functions. However, the role of alternate isoforms in development remains poorlyExpand
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Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod-driven myogenicExpand
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Effect of nitrogen-starvation, light intensity and iron on triacylglyceride/carbohydrate production and fatty acid profile of Neochloris oleoabundans HK-129 by a two-stage process.
Triacylglyceride (TAG) and carbohydrate are potential feedstock for biofuels production. In this study, a two-stage process was applied for enhancing TAG/carbohydrate production in the selectedExpand
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