Yezhou Sun

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XML is rapidly emerging on the World Wide Web as a standard for representing and exchanging data. It is critical to have efficient mechanisms to store and query XML documents to exploit the full power of this new technology. While one approach is to develop native XML repositories that support XML data models and query languages directly, the other approach(More)
XML has emerged as the standard for representing and exchanging data on the World Wide Web. It is critical to have efficient mechanisms to store and query XML data to exploit the full power of this new technology. Several researchers have proposed to use relational databases to store and query XML data. While several algorithms of schema mapping and query(More)
We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As proof of principle, this method was applied to Chlamydia trachomatis-infected epithelial cell monolayers in vitro, successfully obtaining transcriptomes of both C. trachomatis and the host cells at 1(More)
BACKGROUND/AIM Diabetes-associated myocardial dysfunction results in altered gene expression in the heart. We aimed to investigate the changes in gene expression profiles accompanying diabetes-induced cardiomyopathy and its phenotypic rescue by restoration of SERCA2a expression. METHODS/RESULTS Using the Otsuka Long-Evans Tokushima Fatty rat model of type(More)
Hepatic gluconeogenesis is crucial to maintain normal blood glucose during periods of nutrient deprivation. Gluconeogenesis is controlled at multiple levels by a variety of signal transduction and transcriptional pathways. However, dysregulation of these pathways leads to hyperglycemia and type 2 diabetes. While the effects of various signaling pathways on(More)
Chromatin compactness has been considered a major determinant of gene activity and has been associated with specific chromatin modifications in studies on a few individual genetic loci. At the same time, genome-wide patterns of open and closed chromatin have been understudied, and are at present largely predicted from chromatin modification and gene(More)
Our objective was to analyze gene expression pattern in muscles from patients with amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN) compared to controls. Biopsied skeletal muscles from three ALS, three MMN and three control subjects had total RNA extracted and subjected to genome-wide gene expression analysis using Affymetrix(More)
Recently, XML has emerged as a standard for representing and exchanging data on the World Wide Web. As a result, there is a trend of increasing amount of XML documents that publish information on the Web from various data sources. A Document Type Definition (DTD) describes the structure of a set of similar XML documents and serves as the schema for XML(More)
Numerous methods exist for enriching bacterial or mammalian mRNA prior to transcriptome experiments. Yet there persists a need for methods to enrich for mRNA in non-mammalian animal systems. For example, insects contain many important and interesting obligate intracellular bacteria, including endosymbionts and vector-borne pathogens. Such obligate(More)