Yesu Babu Adimulam

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Cyclo-oxygenase-2 (COX-2), a rate-limiting enzyme for prostanoid synthesis, is induced during inflammation and participates in inflammation-mediated cytotoxicity. The discovery of two cyclo-oxygenase (COX) isoenzymes, viz. COX-1 and COX-2, has updated the knowledge of non steroidal anti-inflammatory drugs (NSAIDs). The two COX isoenzymes share structural(More)
The p38 MAPK family of proteins comprised of four members; p38α, p38β, p38γ, and p38δ. All p38 MAPKs are strongly activated by environmental stresses and inflammatory cytokines. MAPKs have been shown to play a pivotal role in diverse diseases, including cancer. Majority of studies have focussed on targeting p38 MAPK isoform alpha. However, the report(More)
Indian forests hold over half the world's tiger population. The forest rangers find it very hard to track the tigers. The combination of Wireless technology, Adhoc Networks and GIS can be helpful in this aspect. We propose a system that uses a combination of Adhoc network, GPS & GIS technologies to help the forest rangers in tracking & identification of the(More)
Unknown proteins or hypothetical proteins exist but have not been characterized or linked to known genes. Domains of unknown function are experimentally identified proteins with no known functional or structural domain. In this paper, the investigation and characterization of the likely functional aspects of a hypothetical protein, YP_001317347.1, from(More)
Selective inhibition of COX-2 provided a new class of anti inflammatory, analgesic, and antipyretic drugs with significantly reduced side effects. It has been reported that inhibiting COX-2 could also be an important strategy for preventing or treating a number of cancers. We report a modified k-means clustering algorithm to cluster groups of compounds(More)
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