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Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids.
Goenlandicine may be a promising anti-AD agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavenging and good ROS inhibitory capacities. Expand
Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation.
The aromatic diamine JSH-23 compound exhibited inhibitory effect with an IC(50) value of 7.1 microM on nuclear factor (NF)-kappaB transcriptional activity in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7, and interfered LPS-induced nuclear translocation of NF- kappaB without affecting IkappaB degradation. Expand
Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill.
In vitro results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible Nitric oxide synthase (iNOS) expression. Expand
Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells.
Results suggest that alantolactone exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 cells by suppressing NF-κB activation and MAPKs phophorylation via downregulation of the MyD88 signaling pathway, and may provide a useful therapeutic approach for inflammation-associated diseases. Expand
Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB
Paeonol inhibited U937 monocyte adhesion to HUVECs stimulated by TNF-alpha, suggesting that it may inhibit the binding of monocytes to endothelium by regulating the production of critical adhesion molecules by T NF-alpha. Expand
Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators In Vitro and In Vivo
The results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxyCurcumin, indicating that the methoxy group had enhanced demeth oxygencur cumin’s anti-inflammation effects. Expand
Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control.
A new method of high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) was developed for the simultaneous quantification of 14 major ginsenosides,Expand
Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages.
Results indicate that glycyrol is an important anti-inflammatory constituent of Glycyrrhizae Radix, and that its anti- inflammatory effect is attributed to the inhibition I-kappaBalpha phosphorylation. Expand
Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells.
Pheophorbide a and pheophytin a are two important candidates of S. japonica as anti-inflammatory agents which can inhibit the production of NO via inhibition of iNOS protein expression, and hold great promise for use in the treatment of various inflammatory diseases. Expand
Isorhamnetin Represses Adipogenesis in 3T3‐L1 Cells
It is shown that isorhamnetin inhibits adipocyte differentiation, as evidenced by reduced triglyceride accumulation and glycerol‐3‐phosphate dehydrogenase (GPDH) activity, and the results of adiponectin promoter assays suggest the inhibition of PPAR‐γ expression as a possible mechanism underlying the isorHAMnetin‐mediated effects. Expand