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NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.

• Yen-yi Zhen, Thorsten Libotte, Martina Munck, Angelika A. Noegel, Elena Korenbaum
• Journal of cell science
• 2002

NUANCE (NUcleus and ActiN Connecting Element) was identified as a novel protein with an alpha-actinin-like actin-binding domain. A human 21.8 kb cDNA of NUANCE spreads over 373 kb on chromosome… (More)

Impact of apoptotic adipose-derived mesenchymal stem cells on attenuating organ damage and reducing mortality in Rat sepsis syndrome induced by cecal puncture and ligation

• Chia-Lo Chang, Steve Leu, +9 authors Hon-Kan Yip
• Journal of Translational Medicine
• 2012

We tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation… (More)

Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction

• Yen-ta Chen, Tzu-hsien Tsai, +10 authors Hon-Kan Yip
• Journal of Translational Medicine
• 2013

This study tested the hypothesis that exendin-4 and sitagliptin can effectively protect kidney from acute ischemia-reperfusion (IR) injury. Adult SD-rats (n = 48) equally divided into group 1 (sham… (More)

Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury.

• Hon-Kan Yip, Yi-Chih Chang, +10 authors Chia-Hung Yen
• Journal of pineal research
• 2013

This study investigated whether melatonin-treated adipose-derived mesenchymal stem cells (ADMSC) offered superior protection against acute lung ischemia-reperfusion (IR) injury. Adult male… (More)

Adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin scaffolds promote angiogenesis, preserve heart function, and reduce left ventricular remodeling in rat acute myocardial…

• Yung-Lung Chen, Cheuk-Kwan Sun, +10 authors Hon-Kan Yip
• American journal of translational research
• 2015

OBJECTIVE This study tested the hypothesis that autologous adipose-derived mesenchymal stem cells (ADMSCs) embedded in platelet-rich fibrin (PRF) can significant promote myocardial regeneration and… (More)

Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction.

• Cheuk-Kwan Sun, Yen-yi Zhen, +10 authors Hon-Kan Yip
• International journal of cardiology
• 2014

BACKGROUND This study tested whether adipose-derived mesenchymal stem cells (ADMSC) embedded in platelet-rich fibrin (PRF) scaffold is superior to direct ADMSC implantation in improving left… (More)

Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.

• Shang-Der Chen, Yen-yi Zhen, +5 authors Yao-Chung Chuang
• CNS neuroscience & therapeutics
• 2016

AIMS Prolonged seizure activity may result in mitochondrial dysfunction and lead to cell death in the hippocampus. Mitochondrial fission may occur in an early stage of neuronal cell death. This study… (More)

Sitagliptin attenuated brain damage and cognitive impairment in mice with chronic cerebral hypo-perfusion through suppressing oxidative stress and inflammatory reaction.

• Tzu-hsien Tsai, Cheuk-Kwan Sun, +7 authors Hon-Kan Yip
• Journal of hypertension
• 2015

BACKGROUND Sitagliptin, a new antidiabetic drug that inhibits dipeptidyl peptidase (DPP)-4 enzyme activity, has been reported to possess neuroprotective property. We tested the protective effects of… (More)

Mixed serum-deprived and normal adipose-derived mesenchymal stem cells against acute lung ischemia-reperfusion injury in rats.

• Cheuk-Kwan Sun, Steve Leu, +10 authors Hon-Kan Yip
• American journal of translational research
• 2015

BACKGROUND This study hypothesized that combined serum-deprived (Sd) and healthy (He) adipose-derived mesenchymal stem cell (ADMSC) therapy is superior to either alone in reducing acute lung… (More)

Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis

• Chung-Feng Hwang, L L Shiu, +10 authors Chang-Han Chen
• PloS one
• 2013

BACKGROUND Nasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at… (More)

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