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Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.

• Yen-Nien Liu, Wassim G. Abou-Kheir, +9 authors Kathleen Kelly
• Molecular and cellular biology
• 2012

Epithelial-mesenchymal transition (EMT) is implicated in various pathological processes within the prostate, including benign prostate hyperplasia (BPH) and prostate cancer progression. However, an… (More)

Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.

• Yen-Nien Liu, JuanJuan Yin, +7 authors Kathleen Kelly
• Molecular and cellular biology
• 2015

Bone metastasis is the hallmark of progressive and castration-resistant prostate cancers. MicroRNA 1 (miR-1) levels are decreased in clinical samples of primary prostate cancer and further reduced in… (More)

EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.

• Yung-Sheng Chang, Wei-Yu Chen, Juan Yin, Heather Sheppard-Tillman, Jiaoti Huang, Yen-Nien Liu
• Cancer research
• 2015

Dysregulation of the EGFR signaling axis enhances bone metastases in many solid cancers. However, the relevant downstream effector signals in this axis are unclear. miR-1 was recently shown to… (More)

Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.

• Philip Martin, Yen-Nien Liu, +6 authors Kathleen Kelly
• The American journal of pathology
• 2011

Loss of PTEN and loss of TP53 are common genetic aberrations occurring in prostate cancer. PTEN and TP53 contribute to the regulation of self-renewal and differentiation in prostate progenitors,… (More)

Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy

• Wei-Yu Chen, Kuo-Tai Hua, +5 authors Ming-Hsien Chien
• International journal of molecular sciences
• 2016

Our previous work demonstrated the epithelial-mesenchymal transition factor, Snail, is a potential marker for predicting the recurrence of localized prostate cancer (PCa). Akt activation is important… (More)

Primary versus castration-resistant prostate cancer: modeling through novel murine prostate cancer cell lines

• Georges E Daoud, Alissar Monzer, +8 authors Wassim G. Abou-Kheir
• Oncotarget
• 2016

Cell lines representing the progression of prostate cancer (PC) from an androgen-dependent to an androgen-independent state are scarce. In this study, we used previously characterized prostate… (More)

Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

• Man Siu, Wassim G. Abou-Kheir, +11 authors Kathleen Kelly
• Oncotarget
• 2014

Activation of EGFR signaling pathway leads to prostate cancer bone metastasis; however, therapies targeting EGFR have demonstrated limited effectiveness and led to drug resistance. miR-203 levels are… (More)

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

• Kuo-Liang Chiu, Yu-Sen Lin, +9 authors Yuh-Pyng Sher
• Oncotarget
• 2017

MicroRNAs (miRNAs), which are endogenous short noncoding RNAs, can regulate genes involved in important biological and pathological functions. Therefore, dysregulation of miRNAs plays a critical role… (More)

MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB

• Shaoxi Niu, Xin Ma, +6 authors Xu Zhang
• PloS one
• 2018

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which shows high aggressiveness and lacks biomarkers. RhoB acts as a tumor suppressor that inhibits the… (More)

New ideas in preventing castration-resistant prostate cancer

• Yuan-Chin Tsai, Yen-Nien Liu
• Oncotarget
• 2017

Prostate cancer is the third leading cause of cancer death in American men. The rationale behind the therapeutic approaches that manage this disease for decades is mainly based on the fundamental… (More)

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