Young-Ji Shiao3
Cheng-Ning Yang2
Huey-Jen Tsay2
Fong-Lee Huang2
3Young-Ji Shiao
2Cheng-Ning Yang
2Huey-Jen Tsay
2Fong-Lee Huang
2Feng-Chang Yen
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  • Wei-Chao Huang, Feng-Chang Yen, Feng-Shiun Shie, Chih-Ming Pan, Young-Ji Shiao, Cheng-Ning Yang +3 others
  • 2010
Background: Overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's disease (AD). Therefore, attenuating microglial clustering can reduce focal neuroinflammation at neuritic plaques. Previously, we identified CCL5 and CCL2 as prominent chemokines that(More)
During liver regeneration, hepatocytes sense the damage and initiate proliferation of the quiescent cells through poorly understood mechanisms. Here, we have used cultured hepatic cells to study the roles played by intercellular calcium in mediating wound-healing processes. Well-differentiated and polarized Hep-G2 cells repaired an experimentally induced(More)
  • Wei-Chao Huang, Feng-Chang Yen, Young-Ji Shiao, Feng-Shiun Shie, Jin-Lieh Chan, Cheng-Ning Yang +3 others
  • 2009
The number of microglia surrounding senile plaques is correlated with the size of plaques in Alzheimer's disease (AD). It is unclear whether more microglia are passively recruited toward larger senile plaques or, conversely, microglia recruited to senile plaques directly contribute to the growth of plaques. In this study, BV-2 microglia were used to(More)
The B lymphocyte-induced maturation protein (Blimp-1) upregulates the expression of syndecan-1 and J chain and represses that of c-myc. We have transfected Blimp-1 into two sublines of the BCL1 B cell lymphoma that represent distinct stages of B cell development in secondary lymphoid tissues. After interleukin (IL)-2 and IL-5 stimulation, the BCL1 3B3 cells(More)
Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin(More)
The aging population is a global phenomenon. The skyrocketing costs of healthcare and the shortage of healthcare providers will soon become a crucial issue all over the world. Taiwan's government executed the Taiwan's Telehealth Pilot Project (TTPP) from July 1, 2008 to December 31, 2008, using healthcare information technology to tackle these problems. The(More)
  • Yuh-Chiang Shen, Young-Ji Shiao, Yen-Jen Sung, Chuen-Neu Wang
  • 2005
Nitric oxide (NO) is a free radical synthesized from L-arginine by three isoforms of NO synthase (NOS). NO is involved in a wide range of physiological functions. It functions as neurotransmitter by modulating the release of glutamate and the neurotransmission of N-methyl-D-aspartate (NMDA) receptor, as neuro-endothelial-derived relaxing factor through the(More)
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