Yean Kyoung Koo

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The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively. Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular(More)
Aspirin is known to suppress platelet function markedly. However, aspirin at concentrations higher than 1 mM was observed to augment 1.3 microM U46619 (a stable thromboxane receptor (TP receptor) agonist) induced human platelet aggregation in this study. Moreover, at a concentration as low as 250 microM aspirin increased the aggregation induced by U46619 in(More)
This paper reports on the green synthesis of heparin-reduced gold nanoparticles and their nanotopography as studied with atomic force microscopy. The study also evaluated the anticoagulant activity of the newly prepared gold nanoparticles. The heparin-reduced gold nanoparticles were homogeneous, showing characteristic surface plasmon resonance bands of(More)
Impaired responsiveness to epinephrine and other catecholamines (CA) were previously reported in platelets of 20 approximately 30% healthy Japanese and Koreans. In the present study, the possible mechanisms of different responsiveness to CA in platelets of CA hypo-responders (CA-HY) and CA good-responders (CA-GR) were investigated. Increased(More)
Traditional medicinal plants possess diverse active constituents for exerting their biological activities. Recently, the innovative applications of plant extracts have revealed their promise as 'green' reducing agents for the reduction of metal ions during the synthesis of metallic nanoparticles. Herein, we report the use of 70% ethanol extracts from(More)
Cinnamomum cassia is a well-known traditional medicine for improvement of blood circulation. An extract of this plant showed both platelet anti-aggregation and blood anti-coagulation effects in preliminary testing. Among the 13 compounds obtained from this plant, eugenol (2), amygdalactone (4), cinnamic alcohol (5), 2-hydroxycinnamaldehyde (7),(More)
The development of new effective drug to stimulate the spermatogenesis on the patients with various causes of male infertility has been proposed in the clinical field. We studied the usefulness of the two herbal extract mixtures, KH-465, consisted of Epimedium Koreanum and Angelica Gigas as a spermatogenesis enhancer. Experimental spermatogenic failure was(More)
Gold nanoparticles were obtained using a green synthesis approach with aqueous earthworm extracts without any additional reducing or capping agents. The gold nanoparticles were characterized using UV-visible spectrophotometry, high-resolution transmission electron microscopy, atomic force microscopy, field emission scanning electron microscopy, X-ray(More)
INTRODUCTION A previous report assigned 35 healthy Koreans into five groups (groups A to E) based on their platelet responsiveness to catecholamines (CA). The present work aimed to elucidate the possible mechanism of heterogeneous responsiveness to CA in normal subjects. MATERIALS AND METHODS The degrees of aggregation in platelet rich plasma (PRP) were(More)
PURPOSE We investigated the protective effect of a mixture of 2 herbal extracts, KH-465, which consisted of Epimedium koreanum Nakai and Angelica gigas Nakai, on spermatogenesis in a luteinizing hormone-releasing hormone (LHRH) agonist-induced rat model of male infertility. MATERIALS AND METHODS Seventy-five 12-week-old male Sprague-Dawley rats were(More)