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Mutation analysis of 73 southern Chinese Wilson's disease patients: identification of 10 novel mutations and its clinical correlation
This study was designed to investigate the molecular basis and the correlation between genotype and phenotype in the southern Chinese patients with Wilson's disease (WD). Genotypes of the ATP7B geneExpand
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Identification and Characterization of Kukoamine Metabolites by Multiple Ion Monitoring Triggered Enhanced Product Ion Scan Method with a Triple-Quadruple Linear Ion Trap Mass Spectrometer.
Kukoamines are a series of bioactive phytochemicals conjugated by a polyamine backbone and phenolic moieties. Understanding the structural diversity of kukoamine metabolites in plants is meaningfulExpand
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Phospholipid analyses by MALDI-TOF/TOF mass spectrometry using 1,5-diaminonaphthalene as matrix
Abstract Phospholipids (PLs) are the major components of cellular membranes and play important biological roles. To effectively identify PL species and avoid chemical background interferences,Expand
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Phytochemical profiles, antioxidant activities of functional herb Abrus cantoniensis and Abrus mollis.
It has been claimed that consumptions of Abrus cantoniensis (AC) and Abrus mollis (AM) as folk beverages and soups are good to cleanse liver toxicants and prevent liver diseases. There is scantExpand
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Mutational characterization of ATP7B gene in 103 Wilson’s disease patients from Southern China: identification of three novel mutations
Wilson’s disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in differentExpand
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Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3- K/Akt/GSK3β pathway by kukoamine from Lycii Cortex
Lycii Cortex (LyC) is widely used as a traditional anti-ageing food ingredient in soup, congee and tea for preventing degenerative disease. However, its bioactive components and modes of action haveExpand
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Identification of kukoamines as the novel markers for quality assessment of Lycii Cortex
Abstract Lycii Cortex (LyC) serves not only as a medical herb but also as a functional food in daily life. In order to identify representative markers for assessment of its function-related quality,Expand
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Sensitivity improvement of kukoamine determination by complexation with dihydrogen phosphate anions in capillary zone electrophoresis
A novel complexation between kukoamines and dihydrogen phosphate ions (DPI) during CZE was discovered to improve the UV signal of kukoamine by around 30‐fold. This complexation formed by electricExpand
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Super-High-Dose Methylprednisolone Does Not Improve Efficacy or Induce Glucocorticoid Resistance in Experimental Allergic Encephalomyelitis
Objective: To investigate whether a super-high dose (SHD) of methylprednisolone (MP) improves its efficacy or induces glucocorticoid (GC) resistance, and to explore the potential mechanisms of GCExpand
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