Ye Yun

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The HOPS complex serves as a tethering complex with GEF activity for Ypt7p in yeast to regulate late endosomal membrane maturation. While the role of HOPS complex is well established in yeast cells, its functional and mechanistic aspects in mammalian cells are less well defined. In this study, we report that RILP, a downstream effector of Rab7, interacts(More)
OBJECTIVE The aim of this meta-analysis was to evaluate the efficacy and safety of levomilnacipran extended-release (ER) in the treatment of major depressive disorder (MDD). METHODS Randomized controlled trials were searched by electronic databases. Unpublished data were also searched by the relevant websites. Weighted mean difference (WMD) and risk ratio(More)
We did not cite a related study which demonstrated that RILP facilitates membrane recruitment of tethering HOPS complex and p150glued subunit of dynein complex, which is regulated by cholesterol sensor ORP1L (Reference 1). In that investigation, RILP interacts with HOPS complex and recruits subunits of HOPS complex to late endosomal membrane, which is(More)
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