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—This paper aims at finding fundamental design principles for hierarchical web caching. An analytical modeling technique is developed to characterize an uncooperative two-level hierarchical caching system where the least recently used (LRU) algorithm is locally run at each cache. With this modeling technique, we are able to identify a characteristic time(More)
— This paper aims at finding fundamental design principles for hierarchical web caching. An analytical mod-eling technique is developed to characterize an uncooperative two-level hierarchical caching system where the least recently used (LRU) algorithm is locally run at each cache. With this modeling technique, we are able to identify a characteristic time(More)
In a simulation study of the estimation of population pharmacokinetic parameters, including fixed and random effects, the estimates and confidence intervals produced by NONMEM were evaluated. Data were simulated according to a monoexponential model with a wide range of design and statistical parameters, under both steady state (SS) and non-SS conditions.(More)
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