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Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) are initially discovered as the essential hematopoietic growth factors regulating bone marrow stem cell proliferation and differentiation, and SCF in combination with G-CSF (SCF+G-CSF) has synergistic effects on bone marrow stem cell mobilization. In this study we have determined the(More)
Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant cancer cells, we designed and synthesized 25 oxindole derivatives based on indirubin by structure-activity relationship analysis. The most potent one was named PH II-7, which(More)
The present study aimed to produce and pathophysiologically evaluate the metallothionein (MT) fusion protein. A recombinant plasmid containing DNA segment coding the pET-glutathione transferase (GST)-small ubiquitin-related modifier (SUMO)-MT fusion protein was inserted into Escherichia coli for expression. The expression level of the fusion protein was(More)
Controller area networks (CAN) are widely used in the development of embedded real-time systems. As embedded systems become more complex, the development of dependable software for such systems is becoming a challenging problem. In this paper, we propose a technique to develop dependable synchronization code for CAN-based embedded systems. Our approach is(More)
The development of correct synchronization code for distributed programs is a challenging task. In this paper, we propose an aspect oriented technique for developing synchronization code for message passing systems. Our approach is to factor out synchronization as a separate aspect, synthesize synchronization code and then compose it with the functional(More)
Introduction of Ag(i) ions into a sulfonic acid functionalized MOF ((Cr)-MIL-101-SO3H) significantly enhances its interactions with olefin double bonds, leading to its much higher selectivities for the separation of C2H4-C2H6 and C3H6-C3H8 at room temperature over the original (Cr)-MIL-101-SO3H and other adsorbents at room temperature.
The problem of synchronization can be formulated in terms of rules constraining the occupancy of regions in different processes, where a region is a block of code whose execution may require synchronization. In this region synchronization problem, the region occupancy rules (or the synchronization policy) can be specified using a global invariant. The task(More)
OBJECTIVE To study the synergistic mechanism between PH II -7 and doxorubicin against multi-drug resistant HL-60/ADR cells and its parent HL-60 cells. METHODS The anti-tumor activity of doxorubicin alone and combined with PH II -7 were measured by MTT assay. RNA was extracted from the cells treated with PH II -7 for different times or doses then the(More)
Controller area networks (CAN) are widely used in the development of embedded real-time systems. As embedded systems are becoming more complex, the development of dependable software for such systems has become a challenging problem. In this paper, we propose a technique to develop dependable synchronization code for CAN-based embedded systems. Our approach(More)
We constructed and expressed an anti-CD3/anti-Pgp (P-glycoprotein) diabody previously. However, the two chains of diabody are associated non-covalently, resulting in being capable of dissociating. The aim of this study is to enhance the stability of the diabody. We introduced cysteine residues into the CD3 or Pgp V-domain to covalently lock the two chains(More)