Ye-Rie Lee

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OBJECTIVES The objective of this study was to investigate the mechanism responsible for the poor oral bioavailability of dimethyl-4',4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB), a hepatoprotective agent, in rats. METHODS DDB was intravenously administered to rats at doses of 0.2-1 mg/kg. To determine the hepatic first-pass(More)
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