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Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only(More)
—Two calibration anomalies of the Defense Meteorological Satellite Program's (DMSP) Special Sensor Microwave Im-ager Sounder (SSMIS) radiometer are examined by using several sources of data. Early orbit mode data from the SSMIS are used to create radiometric images of the warm calibration load that evolve over an entire orbit to elucidate the effects of(More)
Sa-Lrp is a member of the leucine-responsive regulatory protein (Lrp)-like family of transcriptional regulators in Sulfolobus acidocaldarius. Previously, we demonstrated the binding of Sa-Lrp to the control region of its own gene in vitro. However, the function and cofactor of Sa-Lrp remained an enigma. In this work, we demonstrate that glutamine is the(More)
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the cal/val program. In particular, the tasks of diagnosing the root cause(s) of these anomalies as well as the development of ground processing software algorithms to mitigate their impact on F-16 SSMIS and hardware fixes on future instruments necessitated the construction of extensive analysis and simulation tools. The lessons learned from the SSMIS(More)
The environment considered in this research is a massive multiplayer online gaming (MMOG) environment. Each user controls an avatar (an image that represents and is manipulated by a user) in a virtual world and interacts with other users. An important aspect of MMOG is maintaining a fair environment among users (i.e., not give an unfair advantage to users(More)
Web services provide a language-neutral, loosely-coupled, and platform independent way for linking applications within organizations or enterprises across the Internet. In such a scenario, quantitative characteristics such as service execution throughput should be evaluated to measure the system performance. Usually, the first step is to define an abstract(More)
BACKGROUND Chikungunya virus (CHIKV) has caused large outbreaks worldwide in recent years, especially on the islands of the Indian Ocean and India. The virus is transmitted by mosquitoes (Aedes aegypti), which are widespread in China, with an especially high population density in southern China. Analyses of full-length viral sequences revealed the(More)