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  • Seiji Miyahara, Hitoshi Miyakoshi, +16 authors Masayoshi Fukuoka
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2012 (First Published: 12 April 2012)
  • Inhibition of human deoxyuridine triphosphatase (dUTPase) has been identified as a promising approach to enhance the efficacy of 5-fluorouracil (5-FU)-based chemotherapy. This study describes theContinue Reading
  • Hitoshi Miyakoshi, Seiji Miyahara, +11 authors Masayoshi Fukuoka
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2012 (First Published: 12 April 2012)
  • Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated aContinue Reading
  • Seiji Miyahara, Hitoshi Miyakoshi, +16 authors Masayoshi Fukuoka
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2012 (First Published: 14 June 2012)
  • Human deoxyuridine triphosphatase (dUTPase) inhibition is a promising approach to enhance the efficacy of thymidylate synthase (TS) inhibitor based chemotherapy. In this study, we describe theContinue Reading
  • Hitoshi Miyakoshi, Seiji Miyahara, +16 authors Masayoshi Fukuoka
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2012 (First Published: 26 July 2012)
  • Deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as a 5-fluorouracil-based combination chemotherapy. We describe the design and synthesis of a novel classContinue Reading
  • Wakako Yano, Tatsushi Yokogawa, +11 authors Kenichi Matsuo
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2018 (First Published: 1 August 2018)
  • 5-Fluorouracil (5-FU) is an antimetabolite and exerts antitumor activity via intracellularly and physiologically complicated metabolic pathways. In this study, we designed a novel small moleculeContinue Reading