Yayoi Okawa

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If induced pluripotent stem (iPS) cells are to be used to treat damaged tissues or repair organs in elderly patients, it will be necessary to establish iPS cells from their tissues. To determine the feasibility of using this technology with elderly patients, we asked if it was indeed possible to establish iPS cells from the bone marrow (BM) of aged mice. BM(More)
Age-dependent changes in dopaminergic (DA) innervation of the neostriatum (Str) were studied in male F344/N rats. Projections from the substantia nigra pars compacta (SNc) to the neostriatum were quantified using electrophysiological methods at age points from 6 to 24 months. The percentage of DA neurons activated antidromically by electrical stimulation(More)
Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITC-labeled anti-IgG1 in(More)
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