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BACKGROUND Accumulating evidence indicates decreased melatonin levels in patients with schizophrenia. Insomnia, mainly difficulty in falling asleep at night, is commonly reported in this population. Association of insomnia with low or abnormal melatonin rhythms has been repeatedly documented. Melatonin is an endogenous sleep promoter in humans. We(More)
The effects of castration and subsequent testosterone and estradiol treatment and of a single injection of ethylene-1,2-dimethanesulphonate (EDS) on the distribution of [2-125I]iodomelatonin ([ 125I]melatonin) binding sites in the male rat brain were investigated. Castration produced a marked testosterone-reversible decrease in [125I]melatonin binding in(More)
The distribution of melatonin binding sites in synaptosomal preparations from five brain areas of sham-operated and pinealectomized young male rats (maintained in a 14 h light: 10 h darkness cycle; lights on at 5.00 h) was recorded at 10.00, 18.00 and 24.00 h, 18 days after surgery, using 125I-melatonin as a probe. The densities of 125I-melatonin binding(More)
Adult rats were treated with either melatonin, the putative melatonin antagonist N-(2,4 dinitrophenyl)-5-methoxytryptamine (ML-23), their combination, or a vehicle for 16 months via the drinking water. The survival rates, serum testosterone and densities of 125I-melatonin binding sites in the medulla-pons and hypothalamus of the animals at the age of 27-29(More)
A most important function of the circadian system is to ensure that behaviors and metabolism are appropriately timed with respect to the light/dark cycle and photoperiod. Ecological constraints can perturb the daily schedules; would they also impair photoperiodic adaptations? A natural model exists in the golden spiny mouse (Acomys russatus), which is(More)
The effects of castration on 2-[125I]iodomelatonin ([125I]melatonin) binding sites in discrete brain areas were investigated in male Syrian hamsters exposed to long and short days. In hamsters maintained in long days (14 h light: 10 h darkness), castration produced a marked decrease in [125I]melatonin binding in the brain, particularly in the medulla-pons(More)
The distribution of 125I-melatonin binding sites in the male Syrian hamster brain was recorded at 3 times over a 24 h period. The binding in the hypothalamus, hippocampus, medulla-pons and midbrain of the hamsters varied significantly over the 24 h period with different patterns and phases. No such variations were observed in the parietal cortex. Daily(More)
The light-dark cycle is the major time cue for daily and seasonal scheduling of physiological activities. However, non-photic cues (e.g. environmental and social constraints) may also play a significant role. A natural model exists in the golden spiny mouse (Acomys russatus) which is nocturnal when maintained alone but diurnal when sharing a habitat with(More)
The pineal hormone melatonin modulates constitutive protein secretion from murine melanoma M2R cells in vitro, in a cholera-toxin (CTX)-sensitive process, without effecting major changes in cAMP. The effects of melatonin on GTP binding proteins and putative CTX substrates in these cells were investigated. Melatonin enhanced GTP gamma 35S binding and the(More)
Objective: To compare the clinical and radiological outcome between minimally invasive plate osteosynthesis and open reduction and internal fixation in distal tibial fractures. Methods: This randomized controlled trial study was conducted in the department of Orthopedics, Sir Ganga Ram Hospital, Lahore from September 2013 to March 2015. Forty patients(More)