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Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever
TLDR
Results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever.
A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia
TLDR
A novel amyloid precursor protein (APP) mutation is reported that may provide evidence to address the question of how soluble oligomers of Aβ are proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease.
Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response
TLDR
It is demonstrated that two major cell groups in the brain, neuronal cells and non-parenchymal cells, are responsible for the enhanced production of prostaglandins after systemic LPS treatment, and a possible role for blood vessels and leptomeninges in the genesis of fever is proposed.
Multi‐directional differentiation of doublecortin‐ and NG2‐immunopositive progenitor cells in the adult rat neocortex in vivo
TLDR
It is found that a subpopulation of NG2‐immunopositive cells co‐expressing doublecortin (DCX) ubiquitously reside in the adult rat neocortex, and these cells are the major population of proliferating cells in the region.
Unique expression patterns of 5‐HT2A and 5‐HT2C receptors in the rat brain during postnatal development: Western blot and immunohistochemical analyses
TLDR
The results suggest that 5‐HT2 receptors have potential significance in brain development, with a functional difference between 5-HT2A and 5‐ HT2C receptor subtypes.
Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
TLDR
Results indicate that MEK plays a central role in the neuronal death caused by oxidative stress, and a novel MAPK/ERK kinase (MEK) specific inhibitor U0126 profoundly protected HT22 cells against oxidative stress induced by glutamate, which was accompanied by an inhibition of phosphorylation of ERK1/2.
A Genetic Approach to Visualization of Multisynaptic Neural Pathways Using Plant Lectin Transgene
TLDR
A novel genetic approach introducing cDNA for a plant lectin, wheat germ agglutinin (WGA), as a transgene under the control of specific promoter elements, which should greatly facilitate studies on the anatomical and functional organization of the developing and mature nervous system.
Role of cortical spreading depression in the pathophysiology of migraine
TLDR
Evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation, which then contributes to migraine headaches via subsequent activation of trigeminal afferents.
Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Deficit in Fear Response and Conditioned Taste Aversion
TLDR
Immunohistochemical and immunoelectron-microscopic analyses showed that mGluR7 is highly expressed in amygdala and preferentially localized at the presynaptic axon terminals of glutamatergic neurons, which strongly suggest that m GluR 7 is involved in neural processes subserving amygdala-dependent averse responses.
Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography
TLDR
The unique distribution of extrahypothalamic PGE2 binding sites found in this study suggests its involvement in the processing or modulation of viscerosensory, somatosensory and visual inputs as well as in the central integration of autonomic and limbic functions.
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