Yasuyo Nishimura

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BACKGROUND Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, has been implicated in the initiation and progression of cancers. We tested whether YWHAZ acted as a cancer-promoting gene through its activation/overexpression in gastric cancer (GC). METHODS We analysed 7 GC cell lines and 141 primary tumours,(More)
BACKGROUND SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferase for histone H3, p53 and Rb and inhibits their transactivation activities. In this study, we tested whether SMYD2 (1q42) acts as a cancer-promoting factor by being overexpressed in gastric cancer. METHODS We analysed 7 gastric cancer cell lines and 147 primary tumor(More)
A fluorinated 2-nitroimidazole radiosensitizer KU-2285 was given before intraoperative radiotherapy (IORT) to 30 patients with unresectable, unresected or macroscopic residual tumours. Twenty-three patients had pancreatic cancer and five had osteosarcoma. The IORT dose was 30 Gy for unresectable pancreatic cancer and 60 Gy for osteosarcoma. The dose of(More)
TNP-470, a synthetic analogue of fumagillin first isolated from Aspergillus fumigatus, is known to be a potent anti-angiogenic compound. The combined effects on tumour growth and tumour angiogenesis of TNP-470 and hyperthermia were investigated. The tumour used was SCCVII carcinoma of the C3H/He mouse. The tumour response was evaluated by the tumour growth(More)
C3H/He mice bearing SCC VII tumours received 5-bromo-2'-deoxyuridine (BrdU) continuously for 5 days via implanted mini-osmotic pumps in order to label all proliferating (P) cells. The tumours were then heated at 40 degrees C for 60 min. At various time points after heating, tumour-bearing mice were irradiated while alive or after being killed. Immediately(More)
This study determined the effect of potassium (K) sources and rates on plant growth and yield for hydroponic cabbage, celery and lettuce, and also identified deficiency symptoms that would be helpful in treating deficiencies. We used seven treatments: one control treatment with 164.8 mg·L−1 K concentration in nutrient solution and six additional K(More)
A plot experiment was carried out to determine the plant growth and mineral composition of three Solanaceous fruit vegetables for the responses to diurnal temperature alternations. Eggplant, sweet pepper, and tomato were grown in four phytotrons with diurnal temperature fluctuations between day and night temperatures (DIF) set constantly 12 hours day and(More)
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