Yasusuke Miyazaki

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Both insulin resistance and beta-cell dysfunction play a role in the transition from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose tolerance (IGT). The aim of the study was to define the level of glycaemia at which beta-cell dysfunction becomes evident in the context of existing insulin resistance. Insulin response (OGTT)(More)
The transradial approach for catheterization is becoming increasingly more popular. At present, the choice of the right or left radial artery depends on the operator's preference. We examined how the laterality influenced the effectiveness of the approach. Employing Judkins-type catheters, we performed coronary angiography in 232 patients with the left(More)
We aimed to examine the mechanisms by which rosiglitazone improves glycaemic control in Type II (non-insulin-dependent) diabetic patients. Altogether 29 diet-treated diabetic patients were assigned at random to rosiglitazone, 8 mg/day (n = 15), or placebo (n = 14) for 12 weeks. Patients received 75 g OGTT and two-step euglycaemic insulin (40 and 160(More)
This paper describes a 3.5-V operation HBT MMIC power amplifier module for use in GSM/EDGE dual-mode, 900/1800/1900-MHz triple band handset applications. With diode switches and a band select switch built on the MMIC, the module delivers a P/sub out/ of 35.5 dBm and a PAE of about 50% for GSM900, a 33.4-dBm P/sub out/ and a 45% PAE for GSM1800/1900. While(More)
A. Poluektov, A. Bondar, B. D. Yabsley, I. Adachi, H. Aihara, K. Arinstein, V. Aulchenko, T. Aushev, A.M. Bakich, V. Balagura, E. Barberio, A. Bay, K. Belous, M. Bischofberger, A. Bozek, M. Bračko, T. E. Browder, M.-C. Chang, P. Chang, A. Chen, K.-F. Chen, P. Chen, B. G. Cheon, I.-S. Cho, Y. Choi, J. Dalseno, M. Danilov, M. Dash, A. Drutskoy, W. Dungel, S.(More)
Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed. In 40 IGT subjects and 63 sex-, age-, and weight-matched controls with normal glucose tolerance (NGT), we measured (i) indices of insulin sensitivity of fasting(More)
We analyzed single-stranded conformational poly morphisms to screen for mutations and polymorphisms in the insulin receptor gene in subjects with or without insulin resistance. Using this new technique, we demonstrated the existence of mutations in the insulin receptor gene which we had identified previously. In addition, a new mutation was found in exon 20(More)
Correlations between the Index and G provide tests of the validity of this model. And in fact, the close relationships between the Index and G0 and G120 (r2=83%) reported by Gastaldelli et al. support this strongly. The unexplained variance in these relationships (17%) is consistent with the likely measurement errors in the Index (10–15%) and G (~3%). Other(More)
The percutaneous arm approach through the radial or brachial artery for diagnostic cardiac catheterization has advantages, such as a lower incidence of access-site complications and decreased patient discomfort, particularly when smaller diameter catheters are employed. However, the pressure produced by high-flow jets of contrast material exiting from an(More)
A. Matyja, M. Rozanska, I. Adachi, H. Aihara, V. Aulchenko, T. Aushev, S. Bahinipati, A. M. Bakich, V. Balagura, E. Barberio, I. Bedny, V. Bhardwaj, U. Bitenc, A. Bondar, A. Bozek, M. Bračko, J. Brodzicka, T. E. Browder, M.-C. Chang, P. Chang, A. Chen, K.-F. Chen, B. G. Cheon, R. Chistov, I.-S. Cho, Y. Choi, Y. K. Choi, J. Dalseno, M. Dash, S. Eidelman, S.(More)