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Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist,
TLDR
Results indicate that some mGluR1 allosteric antagonists require N760 in TM5 to demonstrate negative modulation of mGlutamate-induced intracellular Ca(2+) mobilization in addition to the reported amino acid residues in TM6 and TM7. Expand
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor
TLDR
4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]N-methylbenzamide 27 as a potent mGluR1 antagonist that demonstrated relatively potent antipsychotic-like effects in several animal models would have great potential for elucidation of mGLUR1 functions in human. Expand
Fate of Mycotoxins during Beer Brewing and Fermentation
TLDR
The levels of aflatoxins, ochratoxin A, patulin, and zearalenone were found to have decreased to less than 20% of their initial concentration after brewing, and the risk of carry-over to beer was reduced for half of the mycotoxins studied. Expand
Simultaneous LC-MS/MS Analysis of Glyphosate, Glufosinate, and Their Metabolic Products in Beer, Barley Tea, and Their Ingredients
TLDR
A method was developed for the simultaneous analysis of glyphosate, glufosinate, and three metabolic products in beer, barley tea, and their ingredients (malt and corn) and enabled a rapid and sensitive analysis of the herbicides to be achieved. Expand
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders.
TLDR
The combined strategy of rapid parallel synthesis and conventional medicinal optimization successfully led to N-cyclopropyl 22 and N-isopropyl isoindolinone analogs 21 and 23 with improved in vivo DMPK profiles that showed an oral antipsychotic-like effect at a dose of 1mg/kg in an animal model. Expand
Degradation of Aflatoxin B1 during the Fermentation of Alcoholic Beverages
TLDR
Risks of AFB1 carryover was still present for both types of beer fermentation but was reduced in the case of wine fermentation because of hydration, and differential analysis of the spiked and unspiked wine samples showed that the degradation compound was AFB2a, a hydrated derivative of USAF1. Expand
Metabolism of Zearalenone in the Course of Beer Fermentation
TLDR
Findings indicate that the health risk to humans due to ZON in beer is reduced during the fermentation process. Expand
Minimization of carryover for high-throughput liquid chromatography with tandem mass spectrometry analysis of 14 mycotoxins in corn grits.
TLDR
It is shown that a highly sensitive method for the simultaneous analysis of mycotoxins over a wide range of concentrations was achieved with minimal carryover, and suggested that the carryover occurred due to the chelation of fumonisins with the metal. Expand
Characterization of Fumonisin A-Series by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry
TLDR
Fragment ion analysis of compounds I–III revealed structural similarities to FBs, only differing by an additional C2H2O in the unknown compounds, and compounds I-III were hypothesized to be N-acetyl analogs of FBs. Expand
Identification and Quantification of Fumonisin A1, A2, and A3 in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry
TLDR
The first identification and quantification of FA1, FA2, and FA3 in corn samples are presented and it is suggested that corn marketed for consumption can be considered as being contaminated with both the fumonisin B-series and with fUMonisin A-series. Expand
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