Yasushi Makiyama

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The cell adhesion molecule CD44 plays an important role in progression of autoimmune diseases or cancer. Administration of anti-CD44 monoclonal antibodies (mAbs) have been reported to have anti-inflammatory or anti-cancer activity. However, our evidence shows that intravenous administration of the anti-CD44 IgG2b mAb IM7 induces systemic shock in mice. To(More)
Background. Endothelin-1 (ET-1) is involved in the progression of nephritis. Glomerular CD44 expression and the accumulation of its ligand hyaluronic acid (HA) both increase in nephritis. HA induces proliferation in many types of cells. We studied possible interactions among ET-1, CD44, and HA in mesangial cell (MC) proliferation, which contributes to the(More)
[Purpose] There have been no investigations into the improvement of activities of daily living among patients suffering from post-stroke depression on admission to convalescent rehabilitation wards in Japan. This study aimed to assess the improvement of activities in daily living in patients with or without post-stroke depression at the time of admission to(More)
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