Yasushi Kikuchi

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The Eker (Tsc2 mutant) rat model of renal carcinoma is an example of Mendelian dominantly inherited predisposition to a specific cancer. Effects of genetic background on renal carcinogenesis in the Eker rat model (Eker/Eker > Eker/BN strain) indicate the presence in the BN rat genome of a modifier gene(s) that suppresses tumorigenesis. The identification of(More)
Cancer is a heritable disorder of somatic cells. Environment and heredity are both important in the carcinogenic process. The Eker rat model of hereditary renal carcinoma (RC) is an example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Forty years after the discovery of the Eker rat in Oslo, we and(More)
BACKGROUND Loss of heterozygosity (LOH) at 13q is one of the most common chromosomal alterations in high-stage prostate cancer, yet little is known about genetic changes in earlier-stage prostate cancer. METHODS We used five microsatellite markers at 13q14, 21, and 33 to compare LOH frequencies in 51 lesions of high-grade prostatic intraepithelial(More)
Hereditary renal cell carcinomas Invariably develop by the age of 1 year In Eker rats. At the histological level, renal cell carcinomas develop through multiple stages from early preneoplastic lesions (e.g., phenotyp ically altered tubules) to adenomas. We previously reported that ionizing radiation induces additional tumors (large adenomas and carcinomas)(More)
Hiroshi Hano,Professor Yutaka Yamaguchi,Professor Masaharu Fukunaga,Associate Professor Akihiko Sakata,Associate Professor Masafumi Suzuki,Associate Professor Masahiro Ikegami,Associate Professor Satoru Chiba,Assistant Professor Yasushi Kikuchi,Assistant Professor Takako Kiyokawa,Assistant Professor Takashi Nikaido,Assistant Professor Hiroyuki(More)
Hereditary renal cell carcinomas Invariably develop by the age of 1 year In Eker rats. At the histological level, renal cell carcinomas develop through multiple stages from early preneoplastic lesions (e.g., phenotyp ically altered tubules) to adenomas. We previously reported that ionizing radiation induces additional tumors (large adenomas and carcinomas)(More)
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