Hideaki Hara15
Masamitsu Shimazawa15
Makoto Araie9
Makiko Osawa7
15Hideaki Hara
15Masamitsu Shimazawa
9Makoto Araie
7Makiko Osawa
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SUMMARY An octree-based mesh generation method is proposed to create reasonable-quality, geometry-adapted unstructured hexahedral meshes automatically from triangulated surface models without any sharp geometrical features. A new, easy-to-implement, easy-to-understand set of refinement templates is developed to perform local mesh refinement efficiently even(More)
PURPOSE To clarify whether endoplasmic reticulum (ER) stress is involved in retinal cell death, using cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with E1A virus), and transgenic mice ER stress-activated indicator (ERAI) mice carrying a human XBP1 and venus a variant of green fluorescent protein (GFP) fusion gene. METHODS(More)
Metallothioneins (MTs) are metal binding proteins and have four isoforms. MT-3, known as growth inhibitory factor (GIF), exists mainly in the central nervous system. It regulates zinc levels and exhibits a neuroprotective effect in the various types of brain diseases. However, the reports demonstrate that the relation between MT-3 and psychiatric disorder(More)
Mesh generation is a critical step in high fidelity computational simulations. High quality and high density meshes are required to accurately capture the complex physical phenomena. A parallel framework has been developed to generate large-scale meshes in a short period of time. A coarse volume mesh is generated first to provide the basis of block(More)
A three-dimensional (3D) geometric model obtained from a 3D device or other approaches is not necessarily watertight due to the presence of geometric deficiencies. These deficiencies must be repaired to create a valid surface mesh on the model as a preprocess of computational engineering analyses. This procedure has been a tedious and labor-intensive step,(More)
In this paper, we propose a robust isotropic tetrahedral mesh generation method. An advancing front method is employed to control local mesh density and to easily preserve the original connectivity of boundary surfaces. Tetrahedra are created by each layer. Instead of preparing a background mesh for mesh spacing control, this information is estimated at the(More)
Glaucoma, an optic neuropathy, is the leading cause of world blindness. In this condition, the damage extends from the retina to the visual center in the brain, although the primary region of damage is thought to be the optic nerve head (ONH), with the lateral geniculate nucleus (LGN) being secondarily affected. We investigated time-dependent alterations in(More)
Intracellular Ca(2+) ([Ca(2+)](i)) oscillations seen in interstitial cells of Cajal (ICCs) are considered to be the primary pacemaker activity in the gut. Here, we show evidence that periodic Ca(2+) release from intracellular Ca(2+) stores produces [Ca(2+)](i) oscillations in ICCs, using cell cluster preparations isolated from mouse ileum. The pacemaker(More)
We examined lateral geniculate nucleus (LGN) degeneration as an indicator for possible diagnosis of glaucoma in experimental glaucoma monkeys using positron emission tomography (PET). Chronic intraocular pressure (IOP) elevation was induced by laser trabeculoplasty in the left eyes of 5 cynomolgus monkeys. Glial cell activation was detected by PET imaging(More)