Yasushi Isobe

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L-asparaginase (L-ASNase) is an important branch of chemotherapy for acute lymphoblastic leukemia (ALL) and some types of non-Hodgkin's lymphoma, including natural killer (NK)-cell lymphoma. Although it mediates hydrolysis of asparagine (Asn) and glutamine (Gln), which are variably required for cancer cell survival, the relative contribution of Asn and Gln(More)
Concurrent chemoradiotherapy has become one of the standard management approaches for newly diagnosed localized nasal natural killer (NK)/T-cell lymphoma (NKTCL). Few data are available on the prognostic biomarkers of NKTCL among patients treated with concurrent chemoradiotherapy. To evaluate the prognostic significance of immunophenotypic biomarkers for(More)
It has come to our attention that we made an error, and 143 cases of the 339 cases analyzed did not fit the criteria for patient selection described in the Patients and Methods section. In addition to the 143 cases without complete data, 5 cases originally categorized in the benign group because of benign pathologic results turned out to have active(More)
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