Yasuo Okutani

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BACKGROUND In Asians, the risk of irinotecan-induced severe toxicities is related in part to UGT1A1*6 (UGT, UDP glucuronosyltransferase) and UGT1A1*28, variant alleles that reduce the elimination of SN-38, the active metabolite of irinotecan. We prospectively studied the relation between the UGT1A1 genotype and the safety of irinotecan-based regimens in(More)
This paper describes a high quality Japanese text to speech (TTS) system, PureTalk. This system is similar to the conventional diphone-based TTS using PSOLA except that PureTalk employs the following novel techniques which enable to produce more intelligible and natural sounding speech: 1) two-stage duration modeling based on a linear regression technique,(More)
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