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OBJECTIVE To examine the effects of Hatha yoga therapy on resilience, brain-derived neurotrophic factor (BDNF) levels, and salivary alpha amylase (SAA) activity in patients with schizophrenia-spectrum disorders. DESIGN AND PARTICIPANTS Single-blinded, randomized controlled study in which outpatients with schizophrenia or related psychotic disorders(More)
BACKGROUND Although the validity and safety of antipsychotic polypharmacy remains unclear, it is commonplace in the treatment of schizophrenia. This study aimed to investigate the degree that antipsychotic polypharmacy contributed to metabolic syndrome in outpatients with schizophrenia, after adjustment for the effects of lifestyle. METHODS A(More)
BACKGROUND It still remains unclear as to how to counteract antipsychotic polypharmacy that remains controversial but common. The objective of this study was to synthesize the clinical evidence to reduce antipsychotic polypharmacy (i.e. use of multiple antipsychotics) in schizophrenia. METHODS A literature search was performed to identify clinical trials(More)
INTRODUCTION Postural instability is a serious concern in patients with schizophrenia-spectrum disorders since it is expected to increase the risk of falls that may lead to fractures. The impact of yoga therapy on postural stability has not been investigated. METHODS In this eight-week single-blind randomized controlled study with an eight-week follow-up,(More)
People with mental disorders often cause distress among their family members. We examined a total of 25 pairs of newly referred psychiatric patients and their family members to investigate the correlations between family burden and patient diagnosis (using the Structured Clinical Interview for DSM-III-R [SCID] axis I disorders), symptomatic severity(More)
OBJECTIVE This study was designed to evaluate efficacy and safety of aripiprazole once-monthly (AOM) by verifying non-inferiority of AOM to oral aripiprazole in Asian patients with schizophrenia. METHOD The study consisted of a screening phase and three phases: an oral conversion phase (≤12weeks), an oral stabilization phase (≤12weeks) and a 52-week(More)