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  • Yoshitugu Miyazaki, Takao Tashiro, +5 authors Pierre Vassalli
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1995 (First Publication: 1 August 1995)
  • The expression level of osteopontin (OPN) mRNA was found to be increased in a macrophage cell line in the presence of recombinant tumor necrosis factor-alpha (TNF-alpha). OPN mRNA level was alsoContinue Reading
  • Yasunori Higuchi, Pedro-Luis Herrera, +7 authors Pierre Vassalli
  • Medicine
  • The Journal of experimental medicine
  • 1992 (First Publication: 1 December 1992)
  • Mice bearing a tumor necrosis factor (TNF) alpha transgene controlled by an insulin promoter developed an increasingly severe lymphocytic insulitis, apparently resulting from the induction ofContinue Reading
    胸腺細胞, 末梢リンパ組織のリンパ球は植物mitogen, PHAによつて刺激される場合に, 炎症滲出細胞の少量を加えると強く活性化され, DNA合成の増強を認める。このことは炎症滲出液中におけるリンパ球の活性が末梢リンパ組織のそれよりも高いことを説明するひとつの機構と考えられる。この炎症滲出細胞によるリンパ球活性化への協力作用は炎症刺激後48~96時間の細胞を含まない滲出液によつても達成され,Continue Reading