Yasumasa Arai

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• Estrogen or aromatizable androgen exerts potent influences on modulating neural development and neural circuit formation in developing sex steroid-sensitive neuroendocrine hypothalamus. Sex steroids can act as a neurotropic factor on neural tissues, stimulating axonal and dendritic growth and synapse formation. Sex steroids are involved in regulation of(More)
Sex differentiation of human brain is mostly dependent on the prenatal exposure to androgen(testosterone). Congenital aromatase deficiency does not disturb male brain development in men. This is quite different from experimental evidence from rodents whose brains need intraneuronal aromatization from androgen to estrogen to induce sex differentiation. There(More)
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