Yasuko Komata

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Entry by tachyzoites of Toxoplasma gondii, the causative agent of toxoplasmosis, into peritoneal cells was investigated with transmission and scanning electron microscopy. The process of entry is initiated by the parasite contacting the host cell with its anterior end, creating a small depression in the plasmalemma of the host cell. Occasionally, a small(More)
The in vitro percutaneous transport of thiamine disulfide (TDS), an oxidized dimer of thiamine, from propylene glycol through excised abdominal rat skin was studied. The application of saturated, long-chain fatty acids [stearic acid (18:0), myristic acid (14:0), and lauric acid (12:0)] as enhancers to the system was also studied. TDS permeated through rat(More)
The permeation and accumulation of lauric acid (12:0) in rat skin as an enhancer for the percutaneous absorption of thiamine disulfide (TDS), using propylene glycol as a vehicle, were determined in vitro. 12:0 barely permeated through skin, and accumulated in skin. The accumulated amount increased increasing concentrations in the vehicle (1-20%). The(More)
Percutaneous absorption of thiamine disulfide, (TDS), a lipophilic derivative of thiamine, from a mixture of propylene glycol (PG) and fatty acid (FA) or its analog through rat skin was tested in vitro. Lauric acid (12:0) enhanced the absorption depending on its concentration in PG and showed a maximal enhancement at 10% w/w. At 10% w/v, lauryl alcohol also(More)
The effect of long chain fatty acid (FA) and its analogs on the accumulation of thiamine disulfide (TDS) in rat skin using propylene glycol as a vehicle was studied in vitro. Lauric acid (12:0) increased the accumulation of TDS in skin, while myristic acid and stearic acid caused a slight decrease in accumulation. Lauryl alcohol and lauric acid methyl ester(More)
The formation of complexes between thiamine disulfide (TDS) orO-acetyl thiamine disulfide (O-acetyl TDS) and fatty acid or fatty acid methyl ester in methanol has been studied by fluorescence quenching and13C NMR relaxation (T1) measurements. The association constants (K-values) of TDS andO-acetyl TDS with fatty acids (from 11∶0 to 18∶0, and 18∶1, 18∶2,(More)
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