Yasuhito Kokunai

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Alkylating agents, often used for chemotherapy in patients with melanoma, can produce O6-alkylguanine (O6AG) which is related to tumor cell killing after treatment with alkylating agents. O6AG is effectively eliminated by O6-methylguanine-DNA methyltransferase (O6MGMT) and its level is correlative to the resistance to alkylating agents. However, little is(More)
Autoimmune disorder is one of the important side effects of interferon-α therapy. Some polymyositis cases as complication of interferon-α therapy were reported, but dermatomyositis were rarely. We report a case of dermatomyositis as a complication of interferon-α therapy for hepatitis C. A 52-year-old Japanese man was treated by combination therapy with(More)
A 12-year-old boy with photosensitivity since 3 years of age presented with small concavities on both cheeks, the nasal root and the dorsal surface of both hands. According to the clinical features, erythropoietic protoporphyria (EPP) was suspected. Urine and blood samples were tested for porphyrin derivatives, which revealed a markedly elevated level of(More)
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