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BACKGROUND Although benzene is known to be myelotoxic and to cause myeloid leukemia in humans, the mechanism has not been elucidated. OBJECTIVES We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by autoxidation, to investigate the toxicity of benzene leading to leukemogenesis. METHODS After exposing(More)
  • Takuro Nishikawa, Emiko Miyahara, Koichiro Kurauchi, Erika Watanabe, Kazuro Ikawa, Kousuke Asaba +4 others
  • 2015
Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed to CY metabolized by S9 fraction of rat liver homogenate mixed with co-factors (CYS9). Cytotoxicity was then(More)
In laser drilling, an assist gas is often used to remove material from the drilling point. In order to design assist gas nozzles to minimize spatter formation, measurements of spatter trajectories are required. We apply computer vision methods to measure the 3D trajectories of spatter particles in a laser cutting event using a stereo camera configuration.(More)
BACKGROUND Intracranial teratoma associated with Down syndrome is rare. With only three previously reported cases, our case is the first one presenting an immature component. CASE DESCRIPTION A 2-month-old boy with trisomy 21 presented with lethargy and head enlargement. A magnetic resonance imaging (MRI) study showed an obstructive hydrocephalus with 0.5(More)
In the present study, we investigate the use of reconfigurable logic devices (RLDs) as intellectual properties (IPs) for system on a chip (SoC). Using RLDs, SoCs can achieve both high performance and high flexibility. However, conventional RLDs have problems related to performance, area, and power consumption. In order to resolve these problems, we(More)
Using optical topography (near-infrared spectroscopy: NIRS), relative changes in oxidized hemoglobin (oxy-Hb) were measured before and after the introduction of Role lettering. Tasks performed during measurements included antegrade (from the subject to other persons) and retrograde (from other persons to the subject) mental imaging and writing tasks. All(More)