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  • Christopher A. Benetatos, Yasuhiro Mitsuuchi, +18 authors Srinivas K. Chunduru
  • Medicine, Biology
  • Molecular Cancer Therapeutics
  • 2014 (First Publication: 21 February 2014)
  • The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP)Expand
  • Stephen M. Condon, Y. Mitsuuchi, +26 authors S. K. Chunduru
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2014 (First Publication: 15 April 2014)
  • Birinapant (1) is a second-generation bivalent antagonist of IAP proteins that is currently undergoing clinical development for the treatment of cancer. Using a range of assays that evaluated cIAP1Expand
  • Yasuhiro Mitsuuchi, C Benetatos, +9 authors SM Condon
  • Biology, Medicine
  • Cell Death Discovery
  • 2017 (First Publication: 16 January 2017)
  • The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines results in induction of cell death. AExpand
    The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP)Expand
  • 2
  • Yasuhiro Mitsuuchi, Christopher A. Benetatos, +7 authors Stephen M. Condon
  • Biology
  • 2014 (First Publication: 1 October 2014)
  • Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA The second mitochondria-derived activator of caspases (SMAC) is thought to exert its pro-apoptotic activity as a homodimericExpand